Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Toxicology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Drug Chem Toxicol. 2022 Sep;45(5):2039-2048. doi: 10.1080/01480545.2021.1903486. Epub 2021 Apr 16.
Poisoning is among the top three common causes of suicidal deaths in Iran. We aimed to evaluate the epidemiologic trend of poisoning and its mortality rate in the largest tertiary toxicology referral center in Iran between 2012 and 2018. A total of 84,242 patients were hospitalized or died due to poisoning in this center during the study period, of whom 2114 (2.5%) died. The most frequent poisonings were those with antiepileptics, sedativehypnotics, and antiparkinson medications (T42) followed by narcotics and psychodysleptics (T40). Psychodysleptics had the highest mortality rate (684; 32.4% of the deaths). Among drugs of abuse, methadone was the most common cause of admission reported in 10,398 cases (12.3%). In conclusion, suicidal or recreational methadone poisoning is becoming the most common cause of admission to poisoning referral wards in Iran. Rigorous supervision of daily dosing at opioid maintenance clinics as well as efforts to control the black-market offering methadone are needed to prevent further methadone-related acute poisonings and deaths.
在伊朗，中毒是自杀死亡的三大主要原因之一。我们旨在评估 2012 年至 2018 年期间，伊朗最大的三级毒理学转诊中心中毒及其死亡率的流行病学趋势。在研究期间，共有 84242 名患者因中毒住院或死亡，其中 2114 人（2.5%）死亡。最常见的中毒是抗癫痫药、镇静催眠药和抗帕金森病药物（T42），其次是麻醉药品和精神药物（T40）。精神药物的死亡率最高（684 人；死亡人数的 32.4%）。在滥用药物中，美沙酮是报告的 10398 例入院的最常见原因（12.3%）。总之，自杀或娱乐性美沙酮中毒正在成为伊朗中毒病房入院的最常见原因。需要严格监督阿片类药物维持诊所的日常剂量，并努力控制美沙酮黑市供应，以防止进一步发生与美沙酮相关的急性中毒和死亡。
