Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, 138673, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117543, Singapore; Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, 119288, Singapore.
Trends Genet. 2021 Jul;37(7):612-615. doi: 10.1016/j.tig.2021.03.004. Epub 2021 Apr 12.
Adolescent idiopathic scoliosis (AIS) is a common skeletal disorder, characterized by abnormal spine curvatures. In zebrafish, cilia-driven cerebrospinal fluid flow and urotensin II pathway activity are required for proper spine morphogenesis. Genetic studies with AIS patients now establish a conservation of the zebrafish findings in the etiology of the disease.
青少年特发性脊柱侧凸（AIS）是一种常见的骨骼疾病，其特征是脊柱异常弯曲。在斑马鱼中，纤毛驱动的脑脊液流动和尾加压素 II 通路活性对于正常的脊柱形态发生是必需的。对 AIS 患者的遗传研究现在确立了斑马鱼研究结果在疾病病因学中的保守性。
