一种在 7T MRI 上测量 MS 患者血管周围空间的新方法。
A Novel Method to Measure Venular Perivascular Spaces in Patients with MS on 7T MRI.
机构信息
Drom the Department of Neurology (I.C.G.), Massachusetts General Hospital, Boston, Massachusetts
Department of Medical Education (A.A.-A.), Icahn School of Medicine at Mount Sinai, New York, New York.
出版信息
AJNR Am J Neuroradiol. 2021 Jun;42(6):1069-1072. doi: 10.3174/ajnr.A7144. Epub 2021 Apr 15.
In MS, inflammatory cells accumulate within the perivascular spaces of acute and chronic lesions. Reliance on perivascular spaces as biomarkers for MS remains uncertain because various studies have reported inconsistencies in perivascular space anatomy. Distinguishing between venular and arteriolar perivascular spaces is pathophysiologically relevant in MS. In this pilot study, we leverage susceptibility-weighted imaging at 7T to better identify perivascular spaces of venular distribution on corresponding high-resolution T2 images.
在多发性硬化症（MS）中，炎症细胞在急性和慢性病变的血管周围空间内积聚。依赖血管周围空间作为 MS 的生物标志物仍然不确定，因为各种研究报告称血管周围空间解剖结构不一致。在 MS 中，区分小静脉和小动脉的血管周围空间在病理生理学上具有相关性。在这项初步研究中，我们利用 7T 下的磁化率加权成像（SWI）更好地识别与相应高分辨率 T2 图像对应的小静脉分布的血管周围空间。
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