Internal Medicine, Crozer-Chester Medical Center, Upland, Pennsylvania, USA.
Harvard Medical School, Boston, Massachusetts, USA
BMJ Case Rep. 2021 Apr 15;14(4):e240573. doi: 10.1136/bcr-2020-240573.
Small-cell carcinoma of the colon is an extremely rare tumour, with poorly understood pathogenesis and unestablished treatment guidelines. The first case was documented in 1919, and only about 100 cases of this condition have been reported to this date. In this case report, we present a case of sigmoid squamous cell carcinoma that eventually led to bowel perforation and was diagnosed on histopathology after emergent surgical intervention. Additionally, we also review the incidence, epidemiology, pathogenesis, immunohistological markers, neogenomics and therapeutic strategies for the same.
结直肠小细胞癌是一种极为罕见的肿瘤，其发病机制尚未完全阐明，也尚未建立明确的治疗指南。首例病例于 1919 年报道，迄今为止，全球仅报道了约 100 例此类病例。在本病例报告中，我们报告了一例乙状结肠鳞状细胞癌病例，该患者最终导致肠穿孔，并在紧急手术干预后通过组织病理学诊断。此外，我们还回顾了该病的发病率、流行病学、发病机制、免疫组织化学标志物、新生组学和治疗策略。
