骨髓瘤-骨髓脂肪细胞轴在肿瘤存活和治疗反应中的作用。
Myeloma-bone marrow adipocyte axis in tumour survival and treatment response.
机构信息
Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Maine Medical Center Research Institute, Scarborough, ME, USA.
出版信息
Br J Cancer. 2021 Sep;125(6):775-777. doi: 10.1038/s41416-021-01371-4. Epub 2021 Apr 15.
Abstract
Multiple myeloma is an incurable cancer of the bone marrow that is dependent on its microenvironment, including bone marrow adipocytes (BMAds). Here, we discuss our findings that the reciprocal interaction of myeloma cells and BMAds, leads to myeloma cell survival and induces metabolic dysfunction and senescence-associated secretory phenotype in BMAds.
摘要
多发性骨髓瘤是一种不可治愈的骨髓癌，依赖于其微环境，包括骨髓脂肪细胞（BMAds）。在这里，我们讨论了我们的发现，即骨髓瘤细胞和 BMAds 的相互作用，导致骨髓瘤细胞存活，并诱导 BMAds 中的代谢功能障碍和衰老相关分泌表型。
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