PROFITH 'PROmoting FITness and Health through physical activity' research group, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA.
Pediatr Res. 2022 Mar;91(4):929-936. doi: 10.1038/s41390-021-01519-1. Epub 2021 Apr 15.
The aim of this study was to investigate the association of endothelial lipase gene (LIPG) polymorphisms with cardiovascular disease (CVD) risk factors in adolescents and their interaction with physical activity.
Six polymorphisms of LIPG were genotyped in 1057 European adolescents (12-18 years old) enrolled in the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) Study. CVD risk factors related to lipid profile, blood pressure, adiposity and glucose regulation were recorded. Physical activity was objectively measured by accelerometry.
The major C allele of rs2000813, the minor T allele of rs2276269 and the minor G allele of rs9951026 were associated with lower levels of several CVD risk factors related to lipid profile. We also found a significant association of the TTACA LIPG haplotype (rs2000812, rs2000813, rs8093249, rs2276269 and rs9951026) with higher concentrations of low-density cholesterol and apolipoprotein B. Finally, the interaction between physical activity and the polymorphisms rs2000813, rs2276269 and rs9951026 had a significant influence on several CVD risk factors.
LIPG polymorphisms were significantly associated with CVD risk factors in European adolescents. Interestingly, alleles of these polymorphisms were associated with a better cardiovascular profile in physically active adolescents only. High physical activity may reduce the development of CVD, modulating its genetic risk.
Using gene-phenotype and gene × environment analyses, we detected associations between the endothelial lipase gene and cardiovascular risk factors, along with interactions with physical activity. This study shows that physical activity may modulate the influence of LIPG gene on cardiovascular risk in adolescents. These results bring insights into the mechanisms by which physical activity positively influences CVD in adolescents.
本研究旨在探讨内皮脂肪酶基因（LIPG）多态性与青少年心血管疾病（CVD）危险因素的关系及其与体力活动的相互作用。
在欧洲青少年健康生活方式与营养研究（HELENA）中，共纳入 1057 名 12-18 岁的欧洲青少年，对其 LIPG 的 6 个基因多态性进行基因分型。记录与血脂谱、血压、肥胖和血糖调节相关的 CVD 危险因素。使用加速度计对体力活动进行客观测量。
rs2000813 的主要 C 等位基因、rs2276269 的次要 T 等位基因和 rs9951026 的次要 G 等位基因与多个与血脂谱相关的 CVD 危险因素的水平降低相关。我们还发现 rs2000812、rs2000813、rs8093249、rs2276269 和 rs9951026 组成的 TTACA LIPG 单倍型与低密度胆固醇和载脂蛋白 B 的浓度升高显著相关。最后，体力活动与 rs2000813、rs2276269 和 rs9951026 多态性之间的相互作用对多个 CVD 危险因素有显著影响。
LIPG 多态性与欧洲青少年的 CVD 危险因素显著相关。有趣的是，这些多态性的等位基因仅与体力活动活跃的青少年的心血管状况较好相关。高水平的体力活动可能会降低 CVD 的发生风险，从而调节其遗传风险。
本研究通过基因-表型和基因-环境分析，检测了内皮脂肪酶基因与心血管危险因素的相关性及其与体力活动的相互作用。本研究表明，体力活动可能会调节 LIPG 基因对青少年心血管风险的影响。这些结果为体力活动对青少年 CVD 产生积极影响的机制提供了新的认识。
