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颌骨空洞表达RANTES/CCL5：将颌骨隐匿性炎症与乳腺癌认识论相联系的病例研究

Jawbone Cavitation Expressed RANTES/CCL5: Case Studies Linking Silent Inflammation in the Jawbone with Epistemology of Breast Cancer.

作者信息

Lechner Johann, Schulz Tilman, Lejeune Beatrice, von Baehr Volker

机构信息

Clinic Integrative Dentistry Munich, Munich, Germany.

Klinikum Bayreuth, Bayreuth, Germany.

出版信息

Breast Cancer (Dove Med Press). 2021 Apr 9;13:225-240. doi: 10.2147/BCTT.S295488. eCollection 2021.

DOI:10.2147/BCTT.S295488
PMID:33859496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8044077/
Abstract

BACKGROUND

The role of signaling pathways as part of the cell-cell communication within cancer progression becomes a crucial area. Chemokine RANTES (regulated upon activation, normal T-cell expressed and secreted), also known as the chemokine C-C motif ligand 5 (CCL5) (R/C), is a protein on which cancer research focus due to its link with aggressive cancer development.

OBJECTIVE

Research on fatty-degenerative osteonecrosis in jawbone (FDOJ) shows striking overexpression of R/C in these areas. Here we try to elucidate a potential link between jawbone-derived R/C and breast cancer (BC) and compare these findings by immunohistochemical staining.

METHODS

Thirty-nine FDOJ samples extracted from 39 BC patients and samples from 19 healthy control were analyzed for R/C expression using bead-based Luminex analysis. R/C levels from 5 BC patients were measured in serum before and after FDOJ surgery. Bone density, histology, R/C expression, and immunohistochemistry were analysed in 4 clinical case studies. The R/C staining of two FDOJ BC patients is compared with the immunohistochemical staining of BC cell preparations.

RESULTS

A high overexpression of R/C was seen in all FDOJ samples. R/C levels in serum were statistically downregulated after FDOJ surgery (p=0.0241).

DISCUSSION

R/C induced "silent inflammation" in BC is widely discussed in scientific papers along with R/C triggering of different signaling pathways, which might be a key point in the development of BC.

CONCLUSION

Hypothesis that FDOJ may serve as a trigger of BC progression through R/C overexpression was set by the authors, who thus inspire clinicians to make aware of FDOJ throughout the dental and medical community in BC cases.

摘要

背景

信号通路作为癌症进展过程中细胞间通讯的一部分，其作用成为一个关键领域。趋化因子RANTES（活化调节、正常T细胞表达和分泌），也称为趋化因子C-C基序配体5（CCL5）（R/C），因其与侵袭性癌症发展的关联而成为癌症研究的重点蛋白。

目的

对颌骨脂肪变性性骨坏死（FDOJ）的研究表明，这些区域中R/C有显著的过表达。在此，我们试图阐明颌骨来源的R/C与乳腺癌（BC）之间的潜在联系，并通过免疫组织化学染色比较这些发现。

方法

使用基于微珠的Luminex分析，对从39例BC患者中提取的39个FDOJ样本以及19例健康对照的样本进行R/C表达分析。在FDOJ手术前后测量5例BC患者血清中的R/C水平。对4个临床病例研究中的骨密度、组织学、R/C表达和免疫组织化学进行分析。将2例FDOJ BC患者的R/C染色与BC细胞制剂的免疫组织化学染色进行比较。

结果

在所有FDOJ样本中均观察到R/C的高过表达。FDOJ手术后血清中的R/C水平在统计学上显著下调（p=0.0241）。

讨论

科学论文中广泛讨论了R/C在BC中诱导的“沉默炎症”以及R/C触发的不同信号通路，这可能是BC发展的关键点。

结论

作者提出了FDOJ可能通过R/C过表达作为BC进展触发因素的假设，从而激励临床医生在BC病例中让整个牙科和医学界认识到FDOJ。

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