Alghamdi Badrah S, Alatawi Yasser, Alshehri Fahad S, Tayeb Haythum O, Tarazi Frank I
Department of Physiology, Neuroscience Unit, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Pre-Clinical Research Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Risk Manag Healthc Policy. 2021 Apr 9;14:1439-1447. doi: 10.2147/RMHP.S302144. eCollection 2021.
Coronavirus disease 2019 (COVID-19) has evolved into a worldwide pandemic and continues to escalate exponentially in many countries across the globe. Recently, higher rates of psychological distress have been reported in several countries during the pandemic. Accordingly, the study aim was to investigate the relationship between public mental health and immune status during the COVID-19 pandemic.
Participants of this cross-sectional study were 2252 national and foreign residents of Saudi Arabia. We used a web-based self-rated questionnaire to measure the association between psychological distress (Depression, Anxiety and Stress Scales [DASS-21]) and immune status (Immune Status Questionnaire [ISQ]) during the COVID-19 pandemic. We also investigated predictors of reduced immune status using binary logistic regression analyses.
Data from 1721 respondents showed that 17.5% of participants scored below the immune status cutoff (ISQ ˂ 6). Mean (± standard deviation) depression, anxiety, and stress scores in the reduced immune status group (ISQ ˂ 6) indicated moderate depression, anxiety, and stress (19.1 ± 11.4; 15.0 ± 9.6; 21.8 ± 11.2, respectively) and were significantly higher than scores in the normal immune status group (ISQ ≥ 6) (8.6 ± 9.1, ˂ 0.0001; 5.0 ± 6.7, ˂ 0.0001; 9.3 ± 9.3, ˂ 0.0001, respectively). The regression analysis showed that age, anxiety, and stress were the only factors that significantly predicted the presence of reduced immune status.
There is an association between mental health problems during the COVID-19 pandemic and immune response in the public, especially in elderly people.
2019年冠状病毒病（COVID-19）已演变成一场全球大流行，并在全球许多国家继续呈指数级升级。最近，在大流行期间，几个国家报告了更高的心理困扰发生率。因此，本研究的目的是调查COVID-19大流行期间公众心理健康与免疫状态之间的关系。
本横断面研究的参与者为沙特阿拉伯的2252名本国和外国居民。我们使用基于网络的自评问卷来测量COVID-19大流行期间心理困扰（抑郁、焦虑和压力量表 [DASS-21]）与免疫状态（免疫状态问卷 [ISQ]）之间的关联。我们还使用二元逻辑回归分析研究了免疫状态降低的预测因素。
来自1721名受访者的数据显示，17.5% 的参与者免疫状态得分低于临界值（ISQ ˂ 6）。免疫状态降低组（ISQ ˂ 6）的抑郁、焦虑和压力平均得分（±标准差）表明存在中度抑郁、焦虑和压力（分别为19.1 ± 11.4；15.0 ± 9.6；21.8 ± 11.2），且显著高于正常免疫状态组（ISQ ≥ 6）的得分（分别为8.6 ± 9.1，˂ 0.0001；5.0 ± 6.7，˂ 0.0001；9.3 ± 9.3，˂ 0.0001）。回归分析表明，年龄、焦虑和压力是显著预测免疫状态降低的唯一因素。
COVID-19大流行期间的心理健康问题与公众尤其是老年人的免疫反应之间存在关联。
