提取物通过诱导凋亡影响AGS胃癌细胞。

Extract Affects AGS Gastric Cancer Cells by Inducing Apoptosis.

作者信息

Kwon Min Ji, Kim Jeong Nam, Park Joon, Kim Yun Tai, Lee Min Jae, Kim Byung Joo

机构信息

Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan 50612, Republic of Korea.

Division of Food Functionality, Korea Food Research Institute, Wanju-gun 55365, Republic of Korea.

出版信息

Int J Med Sci. 2021 Mar 19;18(10):2155-2161. doi: 10.7150/ijms.55212. eCollection 2021.

The anti-cancer effects of extracts (ACE) were identified in AGS gastric cancer cells. Our results showed that ACE inhibited the growth of AGS cells, increased the proportion of sub-G1 phase cells, and depolarized the membrane potential of mitochondria. ACE-induced gastric cancer cell death was associated with Bcl-2, survivin and Bax level changes, and it activated caspase-3 and -9. In addition, it was involved in the activation of MAPKs and increased the reactive oxygen species (ROS). These results suggest that ACE induces apoptosis in AGS gastric cancer cells, and therefore, ACE may have the potential to treat gastric cancer.