Department of Internal Medicine, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
Department of Internal Medicine, Kyung Hee University Korean Medicine Hospital, Seoul 02447, Korea.
Nutrients. 2021 Jul 18;13(7):2455. doi: 10.3390/nu13072455.
The flowering plant genus , which belongs to the family Alismataceae, comprises 11 species, including , , and . (Ze xie in Chinese, Takusha in Japanese, and Taeksa in Korean, ), the tubers of medicinal plants from species, have long been used to treat inflammatory diseases, hyperlipidemia, diabetes, bacterial infection, edema, oliguria, diarrhea, and dizziness. Recent evidence has demonstrated that its extract showed pharmacological activities to effectively reverse cancer-related molecular targets. In particular, triterpenes naturally isolated from have been found to exhibit antitumor activity. This study aimed to describe the biological activities and plausible signaling cascades of and its main compounds in experimental models representing cancer-related physiology and pathology. Available in vitro and in vivo studies revealed that extract possesses anticancer activity against various cancer cells, and the efficacy might be attributed to the cytotoxic and antimetastatic effects of its alisol compounds, such as alisol A, alisol B, and alisol B 23-acetate. Several beneficial functions of triterpenoids found in might be due to p38 activation and inhibition of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways. Moreover, and its triterpenes inhibit the proliferation of cancer cells that are resistant to chemotherapy. Thus, and its triterpenes may play potential roles in tumor attack, as well as a therapeutic remedy alone and in combination with other chemotherapeutic drugs.
该属植物属于泽泻科，由 11 个种组成，包括泽泻、慈姑和野慈姑。（在中国被称为泽泻，在日本被称为 Takusha，在韩国被称为 Taeksa），药用植物的块茎，长期以来一直被用于治疗炎症性疾病、高脂血症、糖尿病、细菌感染、水肿、少尿、腹泻和头晕。最近的证据表明，其提取物表现出有效的逆转与癌症相关的分子靶标的药理活性。特别是，从泽泻属植物中天然分离出的三萜类化合物已被发现具有抗肿瘤活性。本研究旨在描述泽泻属植物及其主要化合物在代表癌症相关生理学和病理学的实验模型中的生物活性和可能的信号级联。现有的体外和体内研究表明，泽泻提取物对各种癌细胞具有抗癌活性，其功效可能归因于其阿利松化合物的细胞毒性和抗转移作用，如阿利松 A、阿利松 B 和阿利松 B 23-醋酸酯。泽泻中发现的几种三萜类化合物的有益功能可能归因于 p38 的激活和抑制磷脂酰肌醇 3-激酶（PI3K）/蛋白激酶 B（Akt）/哺乳动物雷帕霉素靶蛋白（mTOR）信号通路。此外，泽泻及其三萜类化合物抑制对化疗耐药的癌细胞的增殖。因此，泽泻及其三萜类化合物可能在肿瘤攻击中发挥潜在作用，单独使用或与其他化疗药物联合使用均可作为治疗方法。
