电刺激方面的创新利用神经可塑性来恢复运动功能。
Innovations in electrical stimulation harness neural plasticity to restore motor function.
作者信息
Peng Xiaoyu, Hickman Jordan L, Bowles Spencer G, Donegan Dane C, Welle Cristin G
机构信息
Dept. of Neurosurgery, University of Colorado, Anschutz Medical Campus, 12700 East 19th Avenue, Aurora, CO 80045.
ETH Zurich, Department Health Science and Technology, Institute for Neuroscience. Schorenstrasse 16, 8603 Schwerzenbach, Switzerland.
出版信息
Bioelectron Med (Lond). 2018 Dec;1(4):251-263. doi: 10.2217/bem-2019-0002. Epub 2019 Apr 24.
Abstract
Novel technology and innovative stimulation paradigms allow for unprecedented spatiotemporal precision and closed-loop implementation of neurostimulation systems. In turn, precise, closed-loop neurostimulation appears to preferentially drive neural plasticity in motor networks, promoting neural repair. Recent clinical studies demonstrate that electrical stimulation can drive neural plasticity in damaged motor circuits, leading to meaningful improvement in users. Future advances in these areas hold promise for the treatment of a wide range of motor systems disorders.
摘要
新型技术和创新刺激范式使神经刺激系统能够实现前所未有的时空精度和闭环实施。反过来，精确的闭环神经刺激似乎优先驱动运动网络中的神经可塑性，促进神经修复。最近的临床研究表明，电刺激可以驱动受损运动回路中的神经可塑性，从而使使用者得到有意义的改善。这些领域的未来进展有望治疗多种运动系统疾病。
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