Dos Santos Leandro, Maciel Letícia de Oliveira, Gracia Erika Kristina Incerpi, Soares Evelise Aline, Sarto Danielle Aparecida Quintino Silva, Barauna Valério Garrone, Estrela Heder Frank Gianotto, Rocha Carollayne Mendonça, Carvalho Maria das Graças de Souza, Boas Brígida Monteiro Vilas, Garcia José Antônio Dias
Pernambuco Rural Federal University ‒ Serra Talhada Academic Unit (UFRPE ‒ UAST), Serra Talhada, PE 56909-535, Brazil.
Federal Institute of Southern Minas Gerais (IFSULDEMINAS), Muzambinho, MG 37890-000, Brazil.
Prev Nutr Food Sci. 2021 Mar 31;26(1):51-57. doi: 10.3746/pnf.2021.26.1.51.
Cardiovascular diseases are the leading cause of mortality and morbidity worldwide. In this study we compared the effects of oral treatment with red pepper ethereal extracts or simvastatin on dyslipidemia, left ventricle remodeling, and atherosclerotic lesions of low-density lipoprotein (LDL) receptor knockout mice (LDLr) fed a hyperlipidic diet. Forty 3-month-old male mice were distributed into four groups: control (C; animals fed a standard diet), HL (ani-mals fed a hyperlipidic diet), and HL+P or HL+S (animals fed a hyperlipidic diet plus red pepper ethereal extracts or simvastatin, respectively). After 60 days, treatment with both red pepper ethereal extracts and simvastatin prevented dyslipidemia, atherosclerotic lesion progression, and left ventricle hypertrophy. Our results suggest a cardioprotective effect of red pepper ethereal extracts in LDLr mice, which is comparable to the well-known effects of simvastatin.
心血管疾病是全球范围内导致死亡和发病的主要原因。在本研究中，我们比较了口服红辣椒醚提取物或辛伐他汀对喂食高脂饮食的低密度脂蛋白（LDL）受体敲除小鼠（LDLr）的血脂异常、左心室重塑和动脉粥样硬化病变的影响。40只3个月大的雄性小鼠被分为四组：对照组（C；喂食标准饮食的动物）、高脂组（HL；喂食高脂饮食的动物）以及HL+P组或HL+S组（分别喂食高脂饮食加红辣椒醚提取物或辛伐他汀的动物）。60天后，红辣椒醚提取物和辛伐他汀治疗均预防了血脂异常、动脉粥样硬化病变进展和左心室肥厚。我们的结果表明，红辣椒醚提取物对LDLr小鼠具有心脏保护作用，这与辛伐他汀的众所周知的作用相当。
