Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Japan.
Department of Orthopedic Surgery, Konan Kosei Hospital, Japan.
Biomed Res Int. 2021 Mar 29;2021:6622398. doi: 10.1155/2021/6622398. eCollection 2021.
Preventive medicine is important in an aging society. Presarcopenia is the preliminary stage of sarcopenia. Recent advances in bioelectrical impedance analysis (BIA) devices have enabled automatic estimation of neck circumference (NC). However, the agreement between and interchangeability of NC measured manually and that calculated with BIA have not been evaluated. We performed these analyses in the context of health checkups and investigated their associations with presarcopenia.
We enrolled 318 participants who underwent anthropometric measurements, including NC measured manually and by BIA; assessment of physical function; and blood testing. We used Bland-Altman analysis to calculate the agreement between and interchangeability of NC measurements by BIA and by the manual method. We then statistically compared normal participants and those with presarcopenia. Using multivariable analysis, we subsequently investigated significant risk factors for presarcopenia. We defined presarcopenia according to the appendicular skeletal muscle index (aSMI; the ratio of arm and leg skeletal muscle mass to height).
Bland-Altman analysis showed that bias (BIA-manual) was negative overall (-1.07), for male participants (-1.23), and for female participants (-0.96). This finding suggests that BIA measurement is an underestimate in comparison with manual measurement. NC measurement by BIA was found to be interchangeable with that by manual methods, inasmuch as the percentage error was less than 5% overall (4.38%), for male participants (3.81%), and for female participants (4.58%). Univariable analysis revealed that NC was significantly smaller in the participants with presarcopenia than in those without. Multivariable analysis, adjusted for confounding factors, revealed that a decrease in NC was significantly correlated with presarcopenia.
BIA measurements of NC are interchangeable within about 95% with manual measurements. The decrease in NC measured by BIA was significantly associated with presarcopenia in both genders. NC measurement can be used for early detection of presarcopenia.
在老龄化社会中，预防医学很重要。 预肌少症是肌少症的早期阶段。 生物电阻抗分析（BIA）设备的最新进展使得自动估计颈围（NC）成为可能。 但是，手动测量的 NC 与 BIA 计算的 NC 之间的一致性和可互换性尚未得到评估。 我们在健康检查的背景下进行了这些分析，并研究了它们与预肌少症的相关性。
我们招募了 318 名参与者，他们接受了人体测量学测量，包括手动和 BIA 测量的 NC；身体机能评估；和血液测试。 我们使用 Bland-Altman 分析来计算 BIA 和手动方法测量的 NC 之间的一致性和可互换性。 然后，我们对正常参与者和患有预肌少症的参与者进行了统计学比较。 使用多变量分析，我们随后研究了预肌少症的显著危险因素。 我们根据四肢骨骼肌指数（aSMI；手臂和腿部骨骼肌质量与身高的比值）定义了预肌少症。
Bland-Altman 分析显示，总体而言（BIA-手动）偏差为负（-1.07），男性参与者为（-1.23），女性参与者为（-0.96）。 这一发现表明，与手动测量相比，BIA 测量是低估的。 总体而言，BIA 测量的 NC 可与手动方法测量的 NC 互换，因为误差百分比小于 5%（4.38%），男性参与者（3.81%），女性参与者（4.58%）。 单变量分析显示，患有预肌少症的参与者的 NC 明显小于无肌少症的参与者。 经过混杂因素调整的多变量分析显示，NC 的降低与预肌少症显著相关。
BIA 测量的 NC 在大约 95%的范围内与手动测量可互换。 BIA 测量的 NC 降低与两性的预肌少症显著相关。 NC 测量可用于早期发现预肌少症。
