Department of Nutrition, Faculty of Medicine, University of Chile, Independence, 1027, Santiago, Chile.
PROFITH "PROmoting FITness and Health through physical activity" research group. Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sports Science, University of Granada, Ctra de Alfacar s/n C.P., 18071, Granada, Spain.
Sci Rep. 2020 May 20;10(1):8324. doi: 10.1038/s41598-020-65204-9.
Neck circumference (NC) has been proposed as a simple and practical tool, independently associated with cardiometabolic risk factors. However, the association of NC with inter-muscular adipose tissue (IMAT) is still to be determined. We aimed to examine the association of NC with thigh IMAT, and visceral adipose tissue (VAT) measured with computed tomography (CT) in overweight/obese women. 142 premenopausal overweight and obese Caucasian women participated in this cross-sectional study. NC was measured with an inextensible metallic tape above the thyroid cartilage according to International Society for Advancement of Kinanthropometry protocol. Thigh IMAT and VAT volumes were measured with a single cross-sectional CT. Regarding the covariates, fat mass (FM) was assessed with dual-energy x-ray absorptiometry and physical activity was objectively measured with accelerometry. NC was positively associated with thigh IMAT and VAT volumes (standardized β coefficient: β = 0.45, P-value = ≤0.001, β = 0.60, P = ≤ 0.001; respectively), which persisted after adjusting for age, height, overall FM or moderate-to-vigorous physical activity. Our findings show that NC is associated with thigh IMAT volume in overweight and obese premenopausal Caucasian women, regardless of the amount of lower-body fatness. These results suggest underscoring the relevance of NC as a marker of adipose tissue content in thigh skeletal muscle.
颈围（NC）已被提议作为一种简单实用的工具，与心血管代谢危险因素独立相关。然而，NC 与肌间脂肪组织（IMAT）的相关性仍有待确定。我们旨在研究 NC 与大腿 IMAT 和通过计算机断层扫描（CT）测量的内脏脂肪组织（VAT）之间的相关性，研究对象为超重/肥胖的绝经前白人女性。142 名绝经前超重和肥胖的白人女性参与了这项横断面研究。NC 是根据国际人体测量学促进协会的协议，用不可伸展的金属带在甲状软骨上测量的。大腿 IMAT 和 VAT 体积是通过单次 CT 横断面测量的。关于协变量，体脂肪（FM）用双能 X 射线吸收法评估，身体活动用加速度计客观测量。NC 与大腿 IMAT 和 VAT 体积呈正相关（标准化β系数：β=0.45，P 值≤0.001，β=0.60，P=≤0.001；分别），即使在调整了年龄、身高、总体 FM 或中等到剧烈的体力活动后，这种相关性仍然存在。我们的研究结果表明，NC 与超重和肥胖的绝经前白人女性大腿 IMAT 体积相关，而与下半身脂肪量无关。这些结果表明，NC 作为大腿骨骼肌脂肪组织含量的标志物具有重要意义。
