Czyzyk-Krzeska Maria F, Meller Jarek, Landero Figueroa Julio A, Plas David R, Cunningham John T
Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, USA.
Department of Veterans Affairs, Cincinnati Veteran Affairs Medical Center, Cincinnati, OH, USA.
Mol Cell Oncol. 2021 Feb 1;8(2):1859917. doi: 10.1080/23723556.2020.1859917. eCollection 2021.
Tobacco smoking (TS) results in reprogramming of major metabolic pathways, including glycolysis, the citric acid (TCA) cycle, oxidative phosphorylation, and metabolism of aspartate, glutamate and glutamine in clear cell renal cell carcinoma (ccRCC). TS alters the distribution and activities of cadmium, arsenic and copper in a manner mechanistically supporting metabolic remodeling. Alterations in metabolism and metal distribution identify new actionable targets for treatment of ccRCC.
吸烟（TS）会导致透明细胞肾细胞癌（ccRCC）中主要代谢途径的重编程，包括糖酵解、柠檬酸（TCA）循环、氧化磷酸化以及天冬氨酸、谷氨酸和谷氨酰胺的代谢。吸烟以一种在机制上支持代谢重塑的方式改变镉、砷和铜的分布及活性。代谢和金属分布的改变为ccRCC的治疗确定了新的可操作靶点。
