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本文引用的文献

1
Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity.磷酸甘油酸变位酶 1 通过调节 WIP1 活性激活 DNA 损伤修复。
Cell Rep. 2020 Apr 14;31(2):107518. doi: 10.1016/j.celrep.2020.03.082.
2
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012-2016.美国 2012-2016 年诊断的原发性脑和其他中枢神经系统肿瘤 CBTRUS 统计报告。
Neuro Oncol. 2019 Nov 1;21(Suppl 5):v1-v100. doi: 10.1093/neuonc/noz150.
3
Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells.磷酸甘油酸变位酶1调节脱氧核苷酸三磷酸池并促进癌细胞中的同源重组修复。
J Cell Biol. 2017 Feb;216(2):409-424. doi: 10.1083/jcb.201607008. Epub 2017 Jan 25.
4
Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity.磷酸甘油酸变位酶1促进癌细胞迁移，与其代谢活性无关。
Oncogene. 2017 May 18;36(20):2900-2909. doi: 10.1038/onc.2016.446. Epub 2016 Dec 19.
5
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.2016 年世界卫生组织中枢神经系统肿瘤分类：概述。
Acta Neuropathol. 2016 Jun;131(6):803-20. doi: 10.1007/s00401-016-1545-1. Epub 2016 May 9.
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Pyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma.人胶质瘤中丙酮酸激酶 M2 的表达（而非其活性）呈分级特异性上调。
PLoS One. 2013;8(2):e57610. doi: 10.1371/journal.pone.0057610. Epub 2013 Feb 25.
7
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.磷酸甘油酸变位酶 1 协调糖酵解和生物合成以促进肿瘤生长。
Cancer Cell. 2012 Nov 13;22(5):585-600. doi: 10.1016/j.ccr.2012.09.020.
8
Molecular mechanisms of temozolomide resistance in glioblastoma multiforme.胶质母细胞瘤中替莫唑胺耐药的分子机制。
Expert Rev Anticancer Ther. 2012 May;12(5):635-42. doi: 10.1586/era.12.37.
9
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme.己糖激酶 2 是有氧糖酵解的关键调节因子，促进了人多形性胶质母细胞瘤的肿瘤生长。
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10
Evidence for an alternative glycolytic pathway in rapidly proliferating cells.快速增殖细胞中存在替代糖酵解途径的证据。
Science. 2010 Sep 17;329(5998):1492-9. doi: 10.1126/science.1188015.

磷酸甘油酸变位酶1（PGAM1）的过表达通过激活DNA损伤反应促进胶质瘤的放疗和化疗抗性。

Phosphoglycerate mutase 1 (PGAM1) overexpression promotes radio- and chemoresistance in gliomas by activating the DNA damage response.

作者信息

Johannessen Tor-Christian Aase, Mukherjee Joydeep

机构信息

Department of Oncology, Haukeland University Hospital, Bergen, Norway.

Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.

出版信息

Mol Cell Oncol. 2021 Mar 22;8(2):1875804. doi: 10.1080/23723556.2021.1875804. eCollection 2021.

DOI:10.1080/23723556.2021.1875804
PMID:33860077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8018509/
Abstract

The glycolytic enzyme PGAM1 is overexpressed in gliomas where it efficiently facilitates the repair of DNA damage. Mechanistically, PGAM1 prevents inactivation of the ataxia-telangiectasia mutated (ATM) signaling pathway by sequestering the wild-type p53-induced phosphatase 1 (WIP1) in the cytoplasm. Genetic inhibition of PGAM1 expression subsequently sensitizes glioma cells against irradiation and chemotherapy-induced DNA damage.

摘要

糖酵解酶PGAM1在胶质瘤中过表达，它能有效促进DNA损伤的修复。从机制上讲，PGAM1通过将野生型p53诱导的磷酸酶1（WIP1）隔离在细胞质中，防止共济失调毛细血管扩张突变（ATM）信号通路失活。随后，PGAM1表达的基因抑制使胶质瘤细胞对辐射和化疗诱导的DNA损伤敏感。