Bahmaninejad Parvin, Ghafourian Sobhan, Mahmoudi Mina, Maleki Abbas, Sadeghifard Nourkhoda, Badakhsh Behzad
Department of Microbiology, Faculty of Medicine Ilam University of Medical Sciences Ilam Iran.
Clinical Microbiology Research Center Ilam University of Medical Sciences Ilam Iran.
JGH Open. 2021 Mar 18;5(4):493-497. doi: 10.1002/jgh3.12527. eCollection 2021 Apr.
Due to the failure of antibiotic treatment and recurrence of infection in patients with , this study was designed to find the possible cause of treatment failure and recurrence of the infections in Ilam, Iran.
One hundred patients with specific symptoms of infection were selected, and after taking a biopsy specimen, identification of , antibiotic susceptibility assay, and persister cell assay were performed. In addition, after treatment, patients with persister cells were followed for possible recurrence of infection. Furthermore, an antibiotic susceptibility assay was performed.
Our results demonstrated that, among 100 patients, 50% (n = 50) showed positive results for the existence of . Among the susceptible isolates, 18% (n = 9) were persister cells that were sensitive to clarithromycin as confirmed by a 5 folds higher than the Minimal Inhibitory Concentration (MIC) of clarithromycin. The data were confirmed by following up the suspected patients.
Our results demonstrated that persister cells in infections may be responsible to recurrent infection and antibiotic treatment failure. However, more research is needed to obtain more information in this area.
由于[疾病名称]患者抗生素治疗失败且感染复发，本研究旨在探寻伊朗伊拉姆地区[疾病名称]感染治疗失败及复发的可能原因。
选取100例有[疾病名称]感染特定症状的患者，采集活检标本后，进行[病原体名称]鉴定、抗生素敏感性检测及持留菌检测。此外，治疗后对有持留菌的患者进行随访，观察感染是否可能复发。同时，进行抗生素敏感性检测。
我们的结果表明，100例患者中，50%（n = 50）的[病原体名称]检测呈阳性。在敏感分离株中，18%（n = 9）为持留菌，对克拉霉素敏感，其浓度比克拉霉素最低抑菌浓度（MIC）高5倍。对疑似患者的随访证实了这些数据。
我们的结果表明，[疾病名称]感染中的持留菌可能是感染复发及抗生素治疗失败的原因。然而，需要更多研究以获取该领域的更多信息。
