Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University of Munich, Maistrasse 11, 80337, Munich, Germany.
Department of Pathology, LMU Munich, Thalkirchner Street 56, 80337, Munich, Germany.
Arch Gynecol Obstet. 2021 Nov;304(5):1307-1314. doi: 10.1007/s00404-021-06053-3. Epub 2021 Apr 16.
Enzymes with epigenetic functions play an essential part in development of cancer. However, the significance of epigenetic changes in cervical carcinoma as a prognostic factor has not been fully investigated. Nuclear receptor corepressor (NCoR) presents itself as a potentially important element for epigenetic modification and as a potential prognostic aspect in cervical cancer.
By immunohistochemical staining of 250 tumor samples, the expression strength of NCoR was measured and evaluated by immunoreactive score (IRS) in the nucleus and cytoplasm.
A low expression of NCoR in our patients was a disadvantage in overall survival. Expression of NCoR was negatively correlated with viral oncoprotein E6, acetylated histone H3 acetyl K9 and FIGO status, and positively correlated to p53.
Our study has identified epigenetic modification of tumor cells thus seems to be of relevance in cervical cancer as well for diagnosis, as a marker or as a potential therapeutic target in patients with advanced cervical carcinoma.
具有表观遗传功能的酶在癌症的发展中起着至关重要的作用。然而，表观遗传变化在宫颈癌作为预后因素的意义尚未得到充分研究。核受体辅抑制因子（NCoR）作为表观遗传修饰的潜在重要因素和宫颈癌的潜在预后因素。
通过对 250 个肿瘤样本的免疫组织化学染色，用免疫反应评分（IRS）测量细胞核和细胞质中 NCoR 的表达强度。
我们的患者中 NCoR 的低表达在总生存中是不利的。NCoR 的表达与病毒癌蛋白 E6、乙酰化组蛋白 H3 乙酰 K9 和 FIGO 状态呈负相关，与 p53 呈正相关。
我们的研究已经确定了肿瘤细胞的表观遗传修饰，因此在宫颈癌的诊断、作为标志物或作为晚期宫颈癌患者的潜在治疗靶点方面似乎具有相关性。
