Department of Pathology, VU University Medical Center, PO box 7057, 1007 Amsterdam, The Netherlands.
Nat Rev Cancer. 2014 Jun;14(6):395-405. doi: 10.1038/nrc3728.
Infection of cervical epithelium with high-risk human papilloma virus (hrHPV) might result in productive or transforming cervical intraepithelial neoplasia (CIN) lesions, the morphology of which can overlap. In transforming CIN lesions, aberrations in host cell genes accumulate over time, which is necessary for the ultimate progression to cancer. On the basis of (epi)genetic changes, early and advanced transforming CIN lesions can be distinguished. This paves the way for new molecular tools for cervical screening, diagnosis and management of cervical cancer precursor lesions.
高危型人乳头瘤病毒（hrHPV）感染宫颈上皮可能导致具有增殖或转化潜能的宫颈上皮内瘤变（CIN）病变，其形态可能重叠。在转化性 CIN 病变中，宿主细胞基因的异常随着时间的推移而积累，这是最终发展为癌症所必需的。基于（表观）遗传改变，可以区分早期和晚期转化性 CIN 病变。这为宫颈癌前病变的宫颈筛查、诊断和管理的新分子工具铺平了道路。
