非洲从事性工作的女性 HIV 风险评分的推导。
Derivation of an HIV Risk Score for African Women Who Engage in Sex Work.
机构信息
University of Washington School of Medicine, Seattle, WA, USA.
Medical Scientist Training Program, University of Washington, Seattle, WA, USA.
出版信息
AIDS Behav. 2021 Oct;25(10):3292-3302. doi: 10.1007/s10461-021-03235-7. Epub 2021 Apr 16.
No tool exists to stratify HIV risk in contemporary African female sex worker (FSW) populations. Data from a cohort of HIV-negative FSWs in Mombasa, Kenya from 2010 to 2017 were used to conduct a survival analysis assessing predictors of HIV infection. Stepwise regression was used to construct a multivariable model that formed the basis for the score. Seventeen HIV infections occurred over 1247 person-years of follow-up contributed by 670 women. Using depot medroxyprogesterone acetate (DMPA), having a curable sexually transmitted infection (STI), and being married contributed points to the score. HIV incidence was 0.85/100 person-years in a lower-risk group and 3.10/100 person-years in a higher-risk group. In a cohort with overall HIV incidence < 1.50/100 person-years, this risk score identified a subgroup of FSWs with HIV incidence > 3.00/100 person-years, which is the threshold used by the World Health Organization for initiating pre-exposure prophylaxis (PrEP). If validated in an external population, this tool could be useful for targeted PrEP promotion among higher-risk FSWs.
目前尚无工具可用于对当代非洲女性性工作者（FSW）人群进行 HIV 风险分层。本研究使用了来自肯尼亚蒙巴萨 2010 至 2017 年 HIV 阴性 FSW 队列的数据，对 HIV 感染的预测因素进行了生存分析。逐步回归用于构建多变量模型，该模型是评分的基础。在由 670 名女性贡献的 1247 人年随访中，发生了 17 例 HIV 感染。使用长效醋酸甲羟孕酮（DMPA）、患有可治愈的性传播感染（STI）和已婚会给评分加分。低风险组的 HIV 发病率为 0.85/100 人年，高风险组为 3.10/100 人年。在 HIV 总发病率<1.50/100 人年的队列中，该风险评分确定了 HIV 发病率>3.00/100 人年的 FSW 亚组，这是世界卫生组织启动暴露前预防（PrEP）的阈值。如果在外部人群中得到验证，该工具可用于针对高风险 FSW 进行有针对性的 PrEP 推广。
Zotero 插件