Post graduate, Dental students, Research Committee, Department of Orthodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Dental Research Center, Department of Orthodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Exp Med Biol. 2021;1308:225-248. doi: 10.1007/978-3-030-64872-5_16.
Candida albicans is part of the healthy flora in the oral cavity. It can also cause opportunistic infection, which can be deleterious. The most typical type of chronic oral candidiasis is denture stomatitis, and C. albicans is identified as the most crucial organism in this situation. Due to the development of the resistant form of candida, using conventional drugs can sometimes be ineffective. Herbs and naturally imitative bioactive compounds could become a new source for antimycotic therapy. Several review studies suggest that herbal medicine and natural bioactive compounds have antibacterial, antiviral and antifungal effects. Thus, it is hypothesized that these natural products might have beneficial effects on pathogenic oral fungal flora such as C. albicans. Although the effects of herbs have been investigated as antifungal agents in several studies, to the best of our knowledge, the effects of these natural products on C. albicans have not yet been reviewed. Thus, the aim of this study was to review the anti-candida activity (especially C. albicans in oral candidiasis) of herbal medicines and natural bioactive compounds. It is concluded that, in general, medicinal plants and nutraceuticals such as garlic, green tea, propolis, curcumin, licorice root, cinnamon, resveratrol, ginger, and berberine are useful in the treatment of C. albicans in oral candidiasis and could be considered as a safe, accessible, and inexpensive management option in an attempt to prevent and treat oral diseases. However, most of the evidence is based on the in vitro and animal studies, so more clinical trials are needed.
白色念珠菌是口腔内健康菌群的一部分。它也会引起机会性感染，这可能是有害的。最典型的慢性口腔念珠菌病是义齿性口炎，而白色念珠菌被认为是这种情况下最关键的生物体。由于念珠菌耐药形式的发展，使用常规药物有时可能无效。草药和天然类似生物活性化合物可能成为抗真菌治疗的新来源。一些综述研究表明，草药和天然生物活性化合物具有抗菌、抗病毒和抗真菌作用。因此，人们假设这些天然产物可能对致病性口腔真菌菌群（如白色念珠菌）有有益的影响。尽管已经有几项研究调查了草药作为抗真菌剂的作用，但据我们所知，这些天然产物对白色念珠菌的作用尚未得到综述。因此，本研究旨在综述草药和天然生物活性化合物的抗念珠菌活性（特别是口腔念珠菌病中的白色念珠菌）。总的来说，药用植物和营养保健品，如大蒜、绿茶、蜂胶、姜黄素、甘草根、肉桂、白藜芦醇、生姜和小檗碱，在治疗口腔念珠菌病中的白色念珠菌方面是有用的，可以被认为是一种安全、易得和廉价的管理选择，以试图预防和治疗口腔疾病。然而，大多数证据基于体外和动物研究，因此需要更多的临床试验。
