Ghorbani Anahita, Sadrzadeh Ashena, Habibi Emran, Dadgar Kosar, Akbari Jafar, Moosazadeh Mahmood, Hossein Bakhshi, Ahangarkani Fatemeh, Vaezi Afsane
Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.
School of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.
Curr Med Mycol. 2018 Sep;4(3):15-18. doi: 10.18502/cmm.4.3.174.
Denture stomatitis is a chronic inflammation disease of the oral mucosa, which is specified by erythematous lesions mainly in the upper palate. Nystatin as a polyene, a class of antifungal agents, is one of the effective drugs to treat denture stomatitis. Considering the expansion of utilizing herbal drugs to cure many kinds of diseases, the present study was conducted to investigate the effects of (green tea), which has the most chemical and influence similarity with nystatin, against denture stomatitis.
This study was conducted on 22 patients with a positive mycological evidence for denture stomatitis caused by species. The study population was divided into two groups, namely green tea and nystatin, receiving green tea mouthwash 0.5% and nystatin suspension 100,000 U/ml, respectively. The lesion size and number of yeast colonies were measured before and after the treatment.
According to the results, both groups showed reduced lesion size, clinical improvement, and significant reduction of colony count in both group of patients were showedafter the therapeutic. Based on the results of polymerase chain reaction, was the most common species isolated from denture stomatitis. There was no significant difference between the two study groups in terms of species distribution ( ).
Green tea demonstrated a comparable anti- activity with regard to nystatin; therefore, it could be recommended as an alternative treatment.
义齿性口炎是一种口腔黏膜的慢性炎症性疾病，其特征主要是上腭出现红斑性病变。制霉菌素作为一种多烯类抗真菌药物，是治疗义齿性口炎的有效药物之一。鉴于利用草药治疗多种疾病的趋势不断扩大，本研究旨在探讨与制霉菌素具有最多化学和影响相似性的绿茶对义齿性口炎的疗效。
本研究对22例由某菌种引起的义齿性口炎且真菌学证据呈阳性的患者进行。研究人群分为两组，即绿茶组和制霉菌素组，分别接受0.5%的绿茶漱口水和100,000 U/ml的制霉菌素混悬液。在治疗前后测量病变大小和酵母菌落数量。
根据结果，两组患者治疗后病变大小均减小，临床症状改善，且两组患者的菌落计数均显著降低。基于聚合酶链反应结果，某菌是从义齿性口炎中分离出的最常见菌种。两个研究组在菌种分布方面无显著差异（具体数值缺失）。
绿茶在抗某菌活性方面与制霉菌素相当；因此，可推荐其作为替代治疗方法。
