State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing, 100049, China.
Adv Mater. 2021 May;33(21):e2100619. doi: 10.1002/adma.202100619. Epub 2021 Apr 16.
Surgical excision is the main choice for tongue cancer treatment. However, the physiological functions of oral and maxillofacial regions might be severely impaired and high risk of tongue tumor recurrence cannot be avoided. It is thus becoming urgently important to develop alternative strategies for tongue cancer therapy. In this regard, a new class of near-infrared (NIR) light-responsive and peritumoral injectable hydrogel is fabricated with extraordinary photothermal therapy (PTT) for in situ tongue tumors. The as-prepared soft material exhibits good biocompatibility and ultra-strong photothermal effect due to the formed network by negatively charged proteins, chitosan molecules, and Ag AuS nanoparticles (NPs). In a well-constructed in situ tongue tumor model, tumors can be efficiently eradicated by one-time PTT treatment. Importantly, there are no side effects on surrounding normal tissues and potential tumor recurrence is inhibited. In stark contrast to traditional surgical excision, such biomaterials hold great potential for clinical treatment of oral cancers.
手术切除是治疗舌癌的主要选择。然而，口腔和颌面区域的生理功能可能会严重受损，并且舌部肿瘤复发的风险很高。因此，开发替代舌癌治疗策略变得尤为重要。在这方面，制备了一种新型的近红外（NIR）光响应和肿瘤周围可注射水凝胶，用于原位舌肿瘤的光热治疗（PTT）。由于带负电荷的蛋白质、壳聚糖分子和 AgAuS 纳米粒子（NPs）形成的网络，所制备的软材料具有良好的生物相容性和超强的光热效应。在构建良好的原位舌肿瘤模型中，一次性 PTT 治疗可有效消除肿瘤。重要的是，周围正常组织没有副作用，并且抑制了潜在的肿瘤复发。与传统的手术切除相比，这种生物材料具有很大的临床治疗口腔癌的潜力。
