Angelika L, Graf N, Hoffmann W
Kardiologischen Abteilung, Universitäts-Kinderklinik, Homburg/Saar.
Klin Padiatr. 1988 Mar-Apr;200(2):102-7. doi: 10.1055/s-2008-1033694.
Evaluation of the cardiac function of seven patients with beta-thalassemia major was performed by continuous electrocardiography recording during a 24 hr period and during a short term exercise program. A reduction in left ventricular function was assessed by echocardiography and radiocardiography during resting and during exercise. Serious arrhythmias of various forms in the oldest patients (17 and 20 years) were observed during these tests. The younger patients were asymptomatic and their cardiac function tests showed no abnormality. In order to prevent transfusion related cardiac iron toxicity it would seem mandatory to motivate patients for better compliance while on chelation therapy.
通过在24小时期间及短期运动项目期间进行连续心电图记录，对7例重型β地中海贫血患者的心脏功能进行了评估。在静息和运动期间，通过超声心动图和放射性心动图评估左心室功能的降低情况。在这些测试期间，观察到年龄较大的患者（17岁和20岁）出现了各种形式的严重心律失常。较年轻的患者无症状，其心脏功能测试未显示异常。为了预防输血相关的心脏铁中毒，在螯合治疗期间促使患者更好地依从治疗似乎是必要的。
