Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, İstanbul University, İstanbul, Turkey.
Department of Internal Medicine, Faculty of Medicine, İstanbul University, İstanbul, Turkey.
Turk J Med Sci. 2021 Oct 21;51(5):2243-2247. doi: 10.3906/sag-2010-267.
COVID-19 pandemic created concerns among patients receiving immunosuppressive therapy. Frequency of COVID-19 and impact of lockdown on treatment compliance in patients with vasculitis are largely unknown.
Patients with ANCA-associated and large vessel vasculitis that have been followed-up in our clinic were contacted by phone and a questionnaire containing home isolation status, treatment adherence and history of COVID -19 between March 1st and June 30th, 2020 was applied.
The survey was applied to 103 patients (F/M: 59/44, mean age: 53.2±12.5). Thirty-three (32%) patients didn?t attend at least one appointment; 98(95.1%) noted that they spent 3 months in home isolation. Five patients (4.8%) received immunosuppressives irregularly and 3(2.9%) developed symptoms due to undertreatment. Four (3.9%) patients admitted to hospital with a suspicion of COVID-19, but none of them had positive PCR or suggestive findings by imaging. COVID-19 diagnosed in a patient with granulomatosis with polyangiitis during hospitalization for disease flare and she died despite treatment.
Frequency of COVID-19 was low in patients with vasculitis in our single center cohort. Although outpatient appointments were postponed in one-third of our patients, high compliance with treatment and isolation rules ensured patients with vasculitis overcome this period with minimal morbidity and mortality.
COVID-19 大流行引起了接受免疫抑制治疗的患者的担忧。COVID-19 的发病率以及血管炎患者封锁对治疗依从性的影响在很大程度上尚不清楚。
通过电话联系了在我们诊所接受随访的抗中性粒细胞胞浆抗体相关性血管炎和大血管血管炎患者，并应用了包含居家隔离状态、治疗依从性和 2020 年 3 月 1 日至 6 月 30 日期间 COVID-19 病史的问卷。
该调查应用于 103 例患者（F/M：59/44，平均年龄：53.2±12.5）。33 例（32%）患者至少错过了一次就诊；98 例（95.1%）患者表示他们在家隔离了 3 个月。5 例（4.8%）患者免疫抑制剂不规则使用，3 例（2.9%）因治疗不足出现症状。4 例（3.9%）患者因疑似 COVID-19 住院，但均无 PCR 阳性或影像学提示性发现。一名肉芽肿性多血管炎患者在疾病活动期住院时被诊断为 COVID-19，尽管进行了治疗，她仍因此死亡。
在我们的单中心队列中，血管炎患者 COVID-19 的发病率较低。尽管三分之一的患者门诊预约被推迟，但治疗和隔离规则的高度依从性确保了血管炎患者在此期间以最小的发病率和死亡率度过。
