Sullivan D A
Department of Ophthalmology, Harvard Medical School, Boston, MA 02114.
J Steroid Biochem. 1988;30(1-6):429-33. doi: 10.1016/0022-4731(88)90136-7.
The purpose of the present investigation was to examine the influence of the hypothalamic-pituitary axis on the androgen regulation of the ocular secretory immune system. Studies included the following experiments: (1) Testosterone administration significantly increased the immunoglobulin A (IgA) and free secretory component (SC) levels in tears of adult, orchiectomized and sham-hypophysectomized rats, as compared with those in tears of saline-treated controls. (2) Hypophysectomy completely inhibited this androgen effect. (3) Transfer of the pituitary to under the kidney capsule in orchiectomized and hypophysectomized rats did not restore the physiological conditions required for testosterone's stimulation of tear IgA and SC. (4) Selective ablation of the anterior pituitary gland also interfered with the testosterone-induced elevation of tear IgA and SC content. (5) Treatment of orchiectomized and/or hypophysectomized rats with rat prolactin, growth hormone, alpha-melanocyte-stimulating hormone or vehicle for 4 days had no effect on tear SC and/or IgA levels. Overall, these findings demonstrate that an intact hypothalamic-pituitary axis either supports or mediates the androgen control of the secretory immune system in the eye.
本研究的目的是探讨下丘脑 - 垂体轴对眼部分泌性免疫系统雄激素调节的影响。研究包括以下实验：（1）与生理盐水处理的对照组大鼠的泪液相比，给予成年去势和假垂体切除大鼠睾酮显著提高了泪液中免疫球蛋白A（IgA）和游离分泌成分（SC）的水平。（2）垂体切除完全抑制了这种雄激素效应。（3）将垂体移植到去势和垂体切除大鼠的肾包膜下并未恢复睾酮刺激泪液IgA和SC所需的生理条件。（4）选择性切除垂体前叶也干扰了睾酮诱导的泪液IgA和SC含量升高。（5）用大鼠催乳素、生长激素、α-黑素细胞刺激激素或赋形剂处理去势和/或垂体切除大鼠4天，对泪液SC和/或IgA水平没有影响。总体而言，这些发现表明完整的下丘脑 - 垂体轴支持或介导了眼部分泌性免疫系统的雄激素控制。
