Sullivan D A, Allansmith M R
Exp Eye Res. 1986 Feb;42(2):131-9. doi: 10.1016/0014-4835(86)90037-0.
The present study examined the influence of hormones on the tear volume of male rats. The mean tear volume in a population of 2-3-month-old intact rats equaled 4.6 +/- 0.2 microliter. This volume, however, varied depending upon the hormonal environment of the animal. Orchiectomy induced a significant, 46%, increase in the mean tear volume, compared with that of intact rats. Testosterone administration to orchiectomized rats reversed this increase and caused a significant reduction in tear volume. Of interest, this androgen action was prevented if rats were also hypophysectomized. Hypophysectomy alone decrease tear volume and this response was not influenced by later castration. Other endocrine manipulations, including thyroidectomy, adrenalectomy and estrogen treatment of orchiectomized rats had no effect on tear volume. Overall, our results indicate that tear volume may be modulated by hormones from the hypothalamic-pituitary-gonadal axis.
本研究考察了激素对雄性大鼠泪液量的影响。2至3月龄未阉割大鼠群体的平均泪液量为4.6±0.2微升。然而，这一泪液量会因动物的激素环境而有所不同。与未阉割大鼠相比，去势导致平均泪液量显著增加46%。给去势大鼠注射睾酮可逆转这一增加，并使泪液量显著减少。有趣的是，如果大鼠同时接受垂体切除，这种雄激素作用会受到抑制。单独垂体切除会降低泪液量，且这种反应不受随后去势的影响。其他内分泌操作，包括甲状腺切除、肾上腺切除以及对去势大鼠进行雌激素治疗，对泪液量均无影响。总体而言，我们的结果表明，泪液量可能受到下丘脑 - 垂体 - 性腺轴激素的调节。
