给药途径对家兔体内阿司匹林药代动力学的影响。
Effects of administration route on pharmacokinetics of aspirin in the rabbit.
作者信息
Kergueris M F, Bourin M, Larousse C, Lasserre M P, Ortega A
机构信息
Department of Pharmacology, U.E.R. of Medicine, Nantes, France.
出版信息
Methods Find Exp Clin Pharmacol. 1988 Mar;10(3):171-5.
The absorption of aspirin used in the form of lysine acetylsalicylate was studied in the rabbit. Each animal received the drug by three routes: intravenous, gastric and duodenal. Plasma concentrations of acetylsalicylic acid (ASA) and salicylic acid (SA) were compared. ASA plasma concentrations obtained after gastric or duodenal administration were low compared to those after intravenous injection. Concentrations were 2 to 5 times higher after gastric than duodenal administration. SA plasma concentrations were lower at the beginning of the experiment for gastric than for duodenal administration; after 90 min the concentrations were similar. A better absorption of aspirin (as lysine acetylsalicylate) after administration occurred in the stomach than in the duodenum, but the amount of ASA which reached the central compartment was quite poor.
在兔子身上研究了赖氨酸阿司匹林形式的阿司匹林的吸收情况。每只动物通过三种途径给药：静脉注射、胃内给药和十二指肠给药。比较了乙酰水杨酸（ASA）和水杨酸（SA）的血浆浓度。与静脉注射后相比，胃内或十二指肠给药后获得的ASA血浆浓度较低。胃内给药后的浓度比十二指肠给药后高2至5倍。实验开始时，胃内给药的SA血浆浓度低于十二指肠给药；90分钟后，浓度相似。阿司匹林（以赖氨酸阿司匹林形式）给药后在胃中的吸收比在十二指肠中更好，但到达中央室的ASA量相当少。
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