氯氮平致无已知危险因素的口吃：病例报告。
Clozapine-induced stuttering in the absence of known risk factors: a case report.
机构信息
Moi Teaching & Referral Hospital, P.O. BOX 3-30100, Eldoret, Kenya.
出版信息
J Med Case Rep. 2021 Apr 17;15(1):174. doi: 10.1186/s13256-021-02803-8.
BACKGROUND
Stuttering is a rare side effect of clozapine. It has been shown to occur in the presence of one or more factors such as abnormal electrophysiological findings and seizures, extrapyramidal symptoms, brain pathology, and a family history of stuttering. Few case reports have documented the occurrence of clozapine-induced stuttering in the absence of these risk factors.
CASE PRESENTATION
A 29-year-old African male on clozapine for treatment-resistant schizophrenia presented with stuttering at a dosage of 400 mg/day that resolved with dose reduction. Electroencephalogram findings were normal, and there was no clinical evidence of seizures. The patient had no prior history or family history of stuttering, had a normal neurological examination, and showed no signs of extrapyramidal symptoms.
CONCLUSION
Clinicians ought to be aware of stuttering as a side effect of clozapine, even in the absence of known risk factors. Further research should investigate the pathophysiology of clozapine-induced stuttering.
背景
口吃是氯氮平的罕见副作用。已经表明，它在存在一种或多种因素的情况下发生，例如异常电生理发现和癫痫发作、锥体外系症状、脑病理学和口吃家族史。少数病例报告记录了在没有这些危险因素的情况下发生的氯氮平引起的口吃。
病例介绍
一名 29 岁的非洲男性因治疗抵抗性精神分裂症而服用氯氮平，剂量为 400mg/天，出现口吃，剂量减少后缓解。脑电图检查结果正常，无临床癫痫发作证据。患者既往无口吃史或家族史，神经系统检查正常，无锥体外系症状迹象。
结论
临床医生应该意识到口吃是氯氮平的一种副作用，即使在没有已知危险因素的情况下也是如此。应进一步研究氯氮平引起的口吃的病理生理学。
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