氯氮平所致口吃：爱尔兰西部患病率的估计
Clozapine-induced stuttering: an estimate of prevalence in the west of Ireland.
作者信息
Murphy Ruth, Gallagher Anne, Sharma Kapil, Ali Tariq, Lewis Elizabeth, Murray Ivan, Hallahan Brian
机构信息
Department of Psychiatry, National University of Ireland Galway, Newcastle Road, Galway, Ireland.
Department of Psychiatry, National University of Ireland Galway, Galway, Ireland.
出版信息
Ther Adv Psychopharmacol. 2015 Aug;5(4):232-6. doi: 10.1177/2045125315590060.
OBJECTIVES
Clozapine is the most effective treatment available for treatment-resistant schizophrenia; however, it is also associated with a large array of adverse effects that limits its tolerability. A number of previous case reports have noted an association between clozapine and stuttering, however the rate of this possible adverse effect is yet to be established.
METHODS
In this paper, we present six cases of patients treated with clozapine who developed stuttering.
RESULTS
Clozapine was associated with stuttering in 0.92% of individuals treated with clozapine in the region. Clozapine-induced stuttering was associated with an increase in treatment dose or with dose titration at initiation of clozapine in five individuals, with dose reduction or slower dose titration associated with a cessation of stuttering in these cases.
CONCLUSIONS
This is the largest case series to date examining clozapine-induced stuttering and indicates that clozapine-induced stuttering is a relatively common adverse effect that can be managed by a slower titration of clozapine dosage or a modest reduction in dose in most cases.
目的
氯氮平是治疗难治性精神分裂症最有效的药物；然而，它也伴有大量不良反应，这限制了其耐受性。先前有一些病例报告指出氯氮平与口吃之间存在关联，但这种可能的不良反应发生率尚未确定。
方法
在本文中，我们报告了6例接受氯氮平治疗后出现口吃的患者。
结果
在该地区接受氯氮平治疗的患者中，0.92%出现了氯氮平所致口吃。5例氯氮平诱发的口吃与治疗剂量增加或氯氮平起始治疗时的剂量滴定有关，在这些病例中，剂量减少或剂量滴定减慢与口吃停止有关。
结论
这是迄今为止研究氯氮平诱发口吃的最大病例系列，表明氯氮平诱发的口吃是一种相对常见的不良反应，在大多数情况下，可以通过减慢氯氮平剂量滴定速度或适度减少剂量来处理。
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