Ngcamphalala Cebisile, Ostensson Ellinor, Hlongwa Mbuzeleni, Ginindza Themba G
Discipline of Public Health, School of Nursing and Public Health, University of KwaZulu-Natal, Mazisi Kunene Road, Durban, 4041, South Africa.
Department of Children's and Women's Health, Karolinska Institutet, Stockholm, Sweden.
Syst Rev. 2021 Apr 17;10(1):113. doi: 10.1186/s13643-021-01672-y.
Despite the well-documented information on cancer prevention and management, among noncommunicable diseases (NCDs), globally, cancer continues to be the second leading cause of morbidity and mortality with devastating economic consequences. The burden is disproportionately more among developing countries and the extent of evidence available on the economic consequences (direct and indirect costs) of cancer remains unknown in low-income countries particularly in the sub-Saharan region. Understanding the costs of illness is important to inform decision-making on setting up health care policies and informing economic evaluation of interventions. This study aims to map evidence on the distribution of the economic burden (direct and indirect costs) associated with prevention, diagnosis, and treatment of three predominant cancers: prostate, cervix, and female breast in the sub-Saharan Africa.
This scoping review will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews (PRISMA-ScR), and will be conducted following Arksey and O'Malley's framework. We will search PubMed/MEDLINE, Web of Science, CINHAL (via EBSCOhost platform), Science Direct, Cochrane Database of Systematic Reviews, Africa-Wide Information, Google Scholar, and WHO Library. We will perform hand-searching of the reference lists of included studies and other relevant documents. Two reviewers will independently screen all citations, full-text articles, and abstract data. We will include primary studies from all study designs reporting costs associated with prevention, diagnosis and treatment of prostate, cervical, and breast cancers in the sub-Saharan region. Data analysis will involve quantitative (e.g., frequencies) and qualitative (e.g., thematic analysis) methods. A narrative summary of findings will be presented.
This review will map the extent of information available on the economic burden (direct and indirect costs) of prostate, cervical, and breast cancers in the sub-Saharan region. Further guidance for future research in the subject area will be discussed.
Open Science Framework.
尽管关于癌症预防和管理的信息已有充分记录，但在全球非传染性疾病（NCDs）中，癌症仍然是发病率和死亡率的第二大主要原因，具有毁灭性的经济后果。这种负担在发展中国家更为严重，而在低收入国家，尤其是撒哈拉以南地区，关于癌症经济后果（直接和间接成本）的现有证据程度仍然未知。了解疾病成本对于为制定医疗保健政策的决策提供信息以及为干预措施的经济评估提供信息非常重要。本研究旨在梳理撒哈拉以南非洲地区与三种主要癌症（前列腺癌、宫颈癌和女性乳腺癌）的预防、诊断和治疗相关的经济负担（直接和间接成本）分布的证据。
本范围综述将按照系统评价和Meta分析扩展的首选报告项目（PRISMA-ScR）进行报告，并将遵循Arksey和O'Malley的框架进行。我们将搜索PubMed/MEDLINE、科学网、CINHAL（通过EBSCOhost平台）、科学Direct、Cochrane系统评价数据库、全非洲信息、谷歌学术和世卫组织图书馆。我们将对纳入研究的参考文献列表和其他相关文件进行手工检索。两名评审员将独立筛选所有引文、全文文章和摘要数据。我们将纳入所有研究设计的原发性研究，这些研究报告了撒哈拉以南地区前列腺癌、宫颈癌和乳腺癌预防、诊断和治疗相关的成本。数据分析将涉及定量（如频率）和定性（如主题分析）方法。将呈现研究结果的叙述性总结。
本综述将梳理撒哈拉以南地区前列腺癌、宫颈癌和乳腺癌经济负担（直接和间接成本）的可用信息范围。将讨论该主题领域未来研究的进一步指导。
开放科学框架。
