病理性视网膜血管生成中的细胞衰老。
Cellular senescence in pathologic retinal angiogenesis.
机构信息
Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Trends Endocrinol Metab. 2021 Jul;32(7):415-416. doi: 10.1016/j.tem.2021.03.010. Epub 2021 Apr 13.
Abstract
Pathologic angiogenesis causes blindness in many eye diseases. Crespo-Garcia, Tsuruda, and Dejda et al. employed bioinformatics to characterize cell senescence as a primary factor in the common pathogenesis of retinopathies. They validated their findings using human and mouse retina with proliferative retinopathy. Clearance of senescent cells suppressed neovessel growth.
摘要
病理性血管生成导致许多眼病失明。Crespo-Garcia、Tsuruda 和 Dejda 等人采用生物信息学方法将细胞衰老特征化为多种视网膜病变共同发病机制中的一个主要因素。他们使用患有增生性视网膜病变的人类和小鼠视网膜验证了他们的发现。衰老细胞的清除抑制了新血管的生长。
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本文引用的文献
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