Molecular Cell Biology, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan.
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
Sci Rep. 2021 Apr 16;11(1):8349. doi: 10.1038/s41598-021-86512-8.
The piriform cortex (PC) is a major cortical processing center for the sense of smell that receives direct inputs from the olfactory bulb. In mice, the PC consists of three neuronal layers, which are populated by cells with distinct developmental origins. One origin of PC neurons is the pool of Dbx1-expressing neural progenitors located in the ventral pallium at the pallial-subpallial boundary. Since the precise mechanisms of PC neuron development are largely unknown, we sought to define the distribution, timing of neurogenesis, morphology and projection patterns of PC neurons from the Dbx1 lineage. We found that Dbx1-lineage neurons are preferentially distributed in layer 2 and enriched in the ventral portion of the PC. Further, Dbx1 neurons are early-born neurons and contribute to most neuronal subtypes in the PC. Our data also revealed an enrichment of Dbx1-lineage neurons in the ventral anterior PC that project to the orbitofrontal cortex. These findings suggest a specific association between the developmental origin of PC neurons and their neuronal properties.
梨状皮层（PC）是嗅觉的主要皮层处理中心，接收来自嗅球的直接输入。在小鼠中，PC 由三个神经元层组成，这些层由具有不同发育起源的细胞组成。PC 神经元的一个起源是位于腹侧隔核的 Dbx1 表达神经前体细胞池，位于大脑皮层-下皮层边界处。由于 PC 神经元发育的精确机制在很大程度上尚不清楚，我们试图确定来自 Dbx1 谱系的 PC 神经元的分布、神经发生的时间、形态和投射模式。我们发现，Dbx1 谱系神经元优先分布在第 2 层，并且在 PC 的腹侧部分富集。此外，Dbx1 神经元是早生神经元，有助于 PC 中的大多数神经元亚型。我们的数据还揭示了在投射到眶额皮质的 PC 的腹侧前部中 Dbx1 谱系神经元的富集。这些发现表明 PC 神经元的发育起源与其神经元特性之间存在特定关联。
