Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, France.
UMR INSERM, 1027 University of Toulouse III and Faculté de Médecine, France.
J Gerontol A Biol Sci Med Sci. 2021 Jul 13;76(8):1382-1390. doi: 10.1093/gerona/glab094.
Physical activity (PA) demonstrated benefits on brain health, but its relationship with blood biomarkers of neurodegeneration remains poorly investigated. We explored the cross-sectional associations of PA with blood concentrations of neurofilament light chain (NFL) and beta amyloid (Aβ)42/40. We further examined whether the interaction between PA and these biomarkers was longitudinally related to cognition. Four-hundred and sixty-five nondemented older adults engaged in an interventional study and who had a concomitant assessment of PA levels and blood measurements of NFL (pg/mL) and Aβ 42/40 were analyzed. A composite Z-score combining 4 cognitive tests was used for cognitive assessment up to a 4-year follow-up. Multiple linear regressions demonstrated that people achieving 500-999 and 2000+ MET-min/week of PA had lower (ln)NFL concentrations than their inactive peers. Logistic regressions revealed that achieving at least 90 MET-min/week of PA was associated with a lower probability of having high NFL concentrations (ie, ≥91.961 pg/mL [third quartile]). PA was not associated with (Aβ)42/40. Mixed-model linear regressions demonstrated that the reverse relationship between PA and cognitive decline tended to be more pronounced as Aβ 42/40 increased, while it was dampened with increasing levels of (ln)NFL concentrations. This study demonstrates that PA is associated with blood NFL but not with Aβ 42/40. Furthermore, it suggests that PA may attenuate the negative association between amyloid load and cognition, while having high NFL levels mitigates the favorable relationship between PA and cognition. More investigations on non demented older adults are required for further validation of the present findings.
身体活动（PA）对大脑健康有益，但它与神经退行性变的血液生物标志物之间的关系仍未得到充分研究。我们探讨了 PA 与神经丝轻链（NFL）和β淀粉样蛋白（Aβ）42/40 的血液浓度之间的横断面关联。我们进一步研究了 PA 与这些生物标志物之间的相互作用是否与认知的纵向变化有关。465 名认知正常的老年人参与了一项干预性研究，同时评估了 PA 水平和 NFL（pg/mL）和 Aβ42/40 的血液测量值。使用 4 项认知测试的综合 Z 分数进行认知评估，随访时间长达 4 年。多元线性回归显示，达到 500-999 和 2000+MET-min/周 PA 的人，其（ln）NFL 浓度低于不活动的同龄人。逻辑回归显示，达到至少 90 MET-min/周的 PA 与具有较高 NFL 浓度（即≥91.961pg/mL[第三四分位数]）的可能性较低有关。PA 与（Aβ）42/40 无关。混合模型线性回归显示，PA 与认知下降之间的反向关系随着 Aβ42/40 的增加而趋于更加明显，而随着（ln）NFL 浓度的增加而减弱。这项研究表明，PA 与血液 NFL 有关，但与 Aβ42/40 无关。此外，它表明 PA 可能会减轻淀粉样蛋白负荷与认知之间的负相关，而高 NFL 水平则可以减轻 PA 与认知之间的有利关系。需要对认知正常的老年人进行更多的研究，以进一步验证本研究结果。
