Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, 37 Allées Jules Guesdes, 31000, Toulouse, France.
Division of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA.
Sci Rep. 2021 Jun 28;11(1):13394. doi: 10.1038/s41598-021-91038-0.
Neurofilament light chain (NfL) has been associated with cognitive status in multiple neurodegenerative conditions. Studies about plasma NfL and cognitive decline in older adults are still limited. 504 older adults (median age 75 years) who expressed memory complaints were selected from the Multidomain Alzheimer's Preventive Trial (MAPT) and were classified as normal cognition (NC) or mild cognitive impairment (MCI). Cognitive functions were measured as mini mental state examination (MMSE) and composite cognitive score (CCS) over a 4-year period. Plasma NfL was measured at the first or the second year of the MAPT. Mixed-effects linear models were performed to evaluate cross-sectional and longitudinal associations. In the whole population, higher plasma NfL was cross-sectionally associated with lower cognitive functions (MMSE: β = - 0.007, 95% CI [- 0.013, - 0.001]; CCS: β = - 0.003, 95% CI [- 0.006, - 0.001]). In adults with MCI, but not NC, higher plasma NfL was associated with lower CCS at the cross-sectional level (β = - 0.003, 95% CI [- 0.005, - 0.0002]). The upper quartile NfL group further demonstrated more over time decline in CCS (β = - 0.07, 95% CI [- 0.12, - 0.01]) under the MCI status. Plasma NfL can be a promising biomarker of progressive cognition decline in older adults with MCI.
神经丝轻链（NfL）与多种神经退行性疾病的认知状态有关。关于老年人血浆 NfL 与认知能力下降的研究仍然有限。从多领域阿尔茨海默病预防试验（MAPT）中选择了 504 名表达记忆主诉的老年人（中位年龄 75 岁），并将其分类为正常认知（NC）或轻度认知障碍（MCI）。在 4 年的时间里，使用简易精神状态检查（MMSE）和综合认知评分（CCS）来测量认知功能。在 MAPT 的第一年或第二年测量血浆 NfL。采用混合效应线性模型评估横断面和纵向关联。在整个人群中，较高的血浆 NfL 与较低的认知功能呈横断面相关（MMSE：β= - 0.007，95%置信区间[-0.013，-0.001]；CCS：β= - 0.003，95%置信区间[-0.006，-0.001]）。在 MCI 成人中，但在 NC 成人中，较高的血浆 NfL 与横断面的 CCS 较低相关（β= - 0.003，95%置信区间[-0.005，-0.0002]）。在上四分位数 NfL 组中，在 MCI 状态下，CCS 的下降幅度更大（β= - 0.07，95%置信区间[-0.12，-0.01]）。在 MCI 的老年人中，血浆 NfL 可能是认知进行性下降的有前途的生物标志物。
