比较莫昔雌醇（R 2858）与炔雌醇在绝经后妇女中的双盲交叉临床药理学研究。

Double-blind crossover clinical pharmacology study comparing moxestrol (R 2858) and ethinyl estradiol in postmenopausal women.

作者信息

Robyn C, Vekemans M, Rozencweig M, Chigot D, Raynaud J P

出版信息

J Clin Pharmacol. 1978 Jan;18(1):29-34. doi: 10.1002/j.1552-4604.1978.tb01557.x.

DOI:10.1002/j.1552-4604.1978.tb01557.x

Abstract

The potency of 5 migrogram moxestrol (R 2858). 11beta-methoxy-17alpha-ethinyl-estra-1,3,5-[10]-triene-3,17-diol, administered orally, was compared to that of 25 microgram ethinyl estradiol in a double-blind crossover clinical pharmacology study of six postmenopausal women. At these doses, both compounds increased the eosinophilic index and decreased serum LH and FSH levels. A marked effect on circulating prolactin was observed only during ethinyl estradiol treatment.

摘要

在一项针对六名绝经后女性的双盲交叉临床药理学研究中，将口服5微克莫昔司醇（R 2858，11β-甲氧基-17α-乙炔基-雌-1,3,5-[10]-三烯-3,17-二醇）的效力与25微克乙炔雌二醇的效力进行了比较。在这些剂量下，两种化合物均提高了嗜酸性粒细胞指数，并降低了血清促黄体生成素（LH）和促卵泡生成素（FSH）水平。仅在乙炔雌二醇治疗期间观察到对循环催乳素的显著影响。