Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan.
Hum Mol Genet. 2021 Apr 26;30(R1):R37-R41. doi: 10.1093/hmg/ddab028.
By virtue of their cultural, linguistic and genetic legacies, many populations from Sudan have deep histories in the region and retain high genetic diversities. Sudan's location in north east Africa, a unique spot believed to act as a climatic refuge during periods of climate extremes, might have dictated that fate. Among the marked consequences of this diversity is the potential to provide information on the origin and structure of human populations within and outside the continent, as well as migration patterns towards various parts of the African continent, and out of Africa. The diverse Sudanese gene pool further has the potential to inform on genetic adaptations driven by culture and the environment resulting in unique and interesting traits, some of which are yet to be investigated. In addition, these genomes could offer clues to complex issues of causation amidst the challenge of new paradigms in biology underpinned by the genomic revolution.
凭借其文化、语言和遗传遗产，许多来自苏丹的人群在该地区拥有悠久的历史，并保持着高度的遗传多样性。苏丹位于东北非，被认为是气候极端时期的气候避难所，这可能决定了其命运。这种多样性的显著后果之一是有可能提供有关非洲大陆内外人类种群的起源和结构以及向非洲大陆各个地区以及非洲以外地区的迁徙模式的信息。苏丹多样化的基因库还有可能提供有关文化和环境驱动的遗传适应的信息，从而形成独特而有趣的特征，其中一些特征尚未得到研究。此外，这些基因组可能为生物学新范式带来的挑战中提供复杂问题的线索，这些新范式是由基因组革命所支撑的。
