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小儿气道狭窄行滑管成形术的风险分层。

Risk Stratification of Slide Tracheoplasty for Pediatric Airway Stenosis.

机构信息

Department of Cardiothoracic Surgery, Great Ormond Street Hospital for Children, London, United Kingdom.

Department of Radiology, Great Ormond Street Hospital for Children, London, United Kingdom.

出版信息

Ann Thorac Surg. 2022 Apr;113(4):1299-1306. doi: 10.1016/j.athoracsur.2021.04.004. Epub 2021 Apr 20.

Abstract

BACKGROUND

Slide tracheoplasty (STP) is the procedure of choice for treatment of long segmental congenital tracheal stenosis (LSCTS). Few studies predict factors leading to reintervention or mortality after STP. We analyzed a pediatric population to identify such factors and compared the outcome between 2 eras (1995-2012 and 2013-2017).

METHODS

We analyzed 150 consecutive children who underwent STP from February 1995 to December 2017 in our hospital.

RESULTS

Median age and weight were 6.9 months and 6.1 kg. Average tracheal diameter of LSCTS was 2.3 mm. Tracheal stenosis extended into bronchus in 36 patients and distal malacia in 38. Median follow-up was 67 months; mortality was 12.7%. Balloon dilatation was required in 81 patients (54%), stents in 29 (19%), and reoperation in 4 (3%). The presence of malacia, preoperative extracorporeal membrane oxygenation, congenital anomalies, and single lung anatomy increased the risk for reintervention. Cox regression analysis revealed preoperative ventilation to be an independent factor predicting reintervention and single lung tracheal anatomy for mortality. In the current era (after 2013), survival improved from 88% to 97% and stent requirement was reduced from 25% to 11%.

CONCLUSIONS

Slide tracheoplasty can be applied to various airway configurations seen in LSCTS. The requirement for reintervention such as balloon dilatation and stenting is high in the group requiring preoperative ventilation. Mortality is highest in the single lung anatomy group. Centralization of care allowed us to develop the multidisciplinary team expertise to manage this and other rare airway conditions with acceptable outcomes.

摘要

背景

滑动机架成形术(STP)是治疗长节段先天性气管狭窄(LSCTS)的首选方法。很少有研究预测 STP 后导致再次干预或死亡的因素。我们分析了一个儿科人群,以确定这些因素,并比较了两个时代(1995-2012 年和 2013-2017 年)的结果。

方法

我们分析了 1995 年 2 月至 2017 年 12 月期间在我院接受 STP 的 150 例连续儿童患者。

结果

中位年龄和体重分别为 6.9 个月和 6.1kg。LSCTS 的平均气管直径为 2.3mm。36 例患者气管狭窄延伸至支气管,38 例患者远端软化。中位随访时间为 67 个月;死亡率为 12.7%。81 例患者(54%)需要球囊扩张,29 例(19%)需要支架,4 例(3%)需要再次手术。存在软化、体外膜氧合术、先天性异常和单肺解剖结构增加了再次干预的风险。Cox 回归分析显示,术前通气是预测再次干预的独立因素,而单肺气管解剖结构是预测死亡率的独立因素。在当前时代(2013 年后),生存率从 88%提高到 97%,支架需求从 25%降低到 11%。

结论

滑动机架成形术可应用于 LSCTS 中各种气道形态。需要术前通气的患者再次干预,如球囊扩张和支架置入的需求较高。单肺解剖结构组死亡率最高。集中护理使我们能够发展多学科团队专业知识,以管理这一和其他罕见气道疾病,取得可接受的结果。

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