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接受改良滑动气管成形术的先天性气管狭窄患者:单中心技术及长期发病率和死亡率

Congenital Tracheal Stenosis Patients Undergoing Modified Slide Tracheoplasty: Single-Centre Technique and Long-Term Morbidity and Mortality.

作者信息

El-Andari Ryaan, Zibdawi Rami, Holinski Paula, Koller John, Joynt Chloe, Khoo Nee, Lequier Laurance, El-Hakim Hamdy, Al Aklabi Mohammed

机构信息

Division of Cardiac Surgery, University of Alberta, Edmonton, Alberta, Canada.

Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

出版信息

CJC Pediatr Congenit Heart Dis. 2023 Oct 13;3(1):24-32. doi: 10.1016/j.cjcpc.2023.10.003. eCollection 2024 Feb.

Abstract

BACKGROUND

Congenital malformations of the trachea are rare but often life-threatening. Limited data have been published on the outcomes of tracheal reconstruction for congenital tracheal stenosis. We sought to describe the outcomes of patients undergoing tracheal reconstruction over 10 years at our centre.

METHODS

All paediatric patients who underwent long-segment tracheal or bronchial reconstruction from January 1, 2012, to August 31, 2022, were included. The primary outcome was mortality, and secondary outcomes included reoperation and postoperative morbidity. Patients were followed up to 10 years.

RESULTS

Thirty-three patients with ages ranging from 1 day to 12 years (mean 8.5 months) at the time of tracheoplasty or bronchoplasty were included, with 5 patients undergoing off-pump tracheal reconstruction. The most common preoperative comorbidities included patent ductus arteriosus (30.3%), atrial septal defect (27.3%), and prematurity (24.2%). There were no deaths postoperatively within the follow-up period. All patients experienced successful reconstruction with no patients requiring reoperation of the trachea. A total of 14 patients (42.4%) required postoperative balloon dilation, 3 (9.1%) required bronchial repair after tracheal repair, and 2 (6.1%) required bronchoscopic tracheal debridement.

CONCLUSIONS

This single-centre retrospective study provides a large cohort of congenital tracheal reconstruction patients with a survival rate of 100%, experiencing no mortality during follow-up. The majority of patients had preoperative comorbidities and concomitant congenital cardiac defects. Although tracheal reconstruction continues to be complex with significant postoperative morbidity and mortality, the results of our single-centre study demonstrate the continual advancement of this field and the evolving improvement of postoperative outcomes for these patients.

摘要

背景

先天性气管畸形罕见,但常危及生命。关于先天性气管狭窄气管重建术的结果,已发表的数据有限。我们试图描述在我们中心接受超过10年气管重建术患者的结果。

方法

纳入2012年1月1日至2022年8月31日期间接受长段气管或支气管重建术的所有儿科患者。主要结局是死亡率,次要结局包括再次手术和术后并发症。对患者进行长达10年的随访。

结果

纳入33例在气管成形术或支气管成形术时年龄从1天至12岁(平均8.5个月)的患者,其中5例接受非体外循环气管重建术。最常见的术前合并症包括动脉导管未闭(30.3%)、房间隔缺损(27.3%)和早产(24.2%)。随访期内术后无死亡病例。所有患者重建均成功,无患者需要气管再次手术。共有14例患者(42.4%)术后需要球囊扩张,3例(9.1%)在气管修复后需要支气管修复,2例(6.1%)需要支气管镜下气管清创。

结论

这项单中心回顾性研究提供了一大群先天性气管重建患者,生存率为100%,随访期间无死亡病例。大多数患者有术前合并症及先天性心脏缺陷。尽管气管重建仍然复杂,术后有显著的发病率和死亡率,但我们单中心研究的结果表明了该领域的持续进步以及这些患者术后结局的不断改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2573/10964263/6ba6494327f8/gr1.jpg

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