对猫和狗成分的致敏以及对猫致敏儿童症状的预测。

Sensitization to cat and dog components and prediction of symptoms in cat-sensitized children.

机构信息

Siriraj Department of Pediatrics and Allergy, Medical University of Lodz, Copernicus Memorial Hospital in Lodz, Poland.

出版信息

Asian Pac J Allergy Immunol. 2024 Jun;42(2):165-170. doi: 10.12932/AP-070920-0953.

DOI:10.12932/AP-070920-0953

PMID:33865296

Abstract

BACKGROUND

Sensitization to cat and/or dog allergens during childhood represents a risk factor for the development of allergic diseases later in life.

OBJECTIVE

The study investigated the association of patterns of sensitization to cat and dog allergen components with clinical symptoms of allergy to these furry animals among cat-sensitized children.

METHODS

The children were evaluated for the presence of bronchial asthma, atopic dermatitis and allergic rhinitis. Their mothers completed a questionnaire on pet exposure at home. Levels of serum IgE cat epitopes Fel d (1, 2, 4), as well as dog components Can f (1, 2, 3, 5) were measured in all the studied children.

RESULTS

Respiratory symptoms following exposure to the cat allergen were most common in children with Fel d 2 epitope (p = 0.041). After contact with a dog, respiratory symptoms were most common in children with Can f 1 epitope (p = 0.042), atopic dermatitis in children with sensitization to both Can f 1 (p = 0.009) and Can f 2 (p = 0.002), whereas eye symptoms occurred mostly in children with Can f 3 (p = 0.039).

CONCLUSIONS

Molecular diagnosis in patients with pet allergy may help clinicians to predict clinical symptoms and their severity.

摘要

背景

儿童时期对猫和/或狗过敏原的致敏是日后发生过敏疾病的危险因素。

目的

本研究旨在调查对猫和狗过敏原成分的致敏模式与猫致敏儿童对这些毛茸茸动物的过敏症状之间的关联。

方法

评估儿童是否存在支气管哮喘、特应性皮炎和过敏性鼻炎。其母亲在家中宠物暴露情况方面完成问卷调查。在所有研究儿童中测量血清 IgE 猫过敏原表位 Fel d (1、2、4)以及狗过敏原表位 Can f (1、2、3、5)水平。

结果

接触猫过敏原后出现呼吸道症状在 Fel d 2 表位的儿童中最为常见（p = 0.041）。与狗接触后，有 Can f 1 表位致敏的儿童出现呼吸道症状最为常见（p = 0.042），同时有 Can f 1 和 Can f 2 致敏的儿童出现特应性皮炎（p = 0.009 和 p = 0.002），而有 Can f 3 致敏的儿童出现眼部症状最为常见（p = 0.039）。