鼻激发试验与猫狗提取物：基于分子成分的结果。

Nasal Provocation Test with Cat and Dog Extracts: Results according to Molecular Components.

机构信息

Group of Clinical and Experimental Allergy, Clinic "IPS Universitaria", University of Antioquia, Medellín, Colombia.

Medicine Department, University Corporation, Rafael Nuñez, Cartagena, Colombia.

出版信息

Pulm Med. 2020 Jan 24;2020:6365314. doi: 10.1155/2020/6365314. eCollection 2020.

BACKGROUND

IgE sensitization (atopy) to pets is commonly evaluated using pet dander extracts. However, the diagnosis by components seems to be more adequate to evaluate the clinical relevance (allergy) of sIgE sensitization.

OBJECTIVE

To study the association between IgE sensitization to pet allergen components and clinical symptoms. . Dander extracts and sIgE levels to pet components (Can f 1, Can f 2, Can f 3, Can f 5, Fel d 1, Fel 2, and Fel 4) were measured in a rhinitis group ( = 101) and a control group ( = 101) and a control group (.

RESULTS

Dog (34.6% vs. 23.5%) and cat dander (26.7% vs. 8.8%, = 0.05) IgE sensitization was frequent among rhinitis and no-rhinitis subjects, and it was similar to dog (29.7% vs. 20.5%) and cat (18.8% vs. 8.8%) components. Polysensitization for dog (3.1, 95% CI: 1.5 to 6.1, = 0.05) IgE sensitization was frequent among rhinitis and no-rhinitis subjects, and it was similar to dog (29.7% vs. 20.5%) and cat (18.8% vs. 8.8%) components. Polysensitization for dog (3.1, 95% CI: 1.5 to 6.1, = 0.05) IgE sensitization was frequent among rhinitis and no-rhinitis subjects, and it was similar to dog (29.7% vs. 20.5%) and cat (18.8% vs. 8.8%) components. Polysensitization for dog (3.1, 95% CI: 1.5 to 6.1.

CONCLUSIONS

Sensitization to pet dander extract identifies atopic patients, but its utility to predict clinical relevance is poor. Allergenic components could help to define the clinical relevance of sensitization to furry animals and could reduce the need for provocation test.

背景

使用宠物皮屑提取物通常可以评估 IgE 致敏（过敏）。然而，成分诊断似乎更适合评估 sIgE 致敏的临床相关性（过敏）。

目的

研究宠物过敏原成分的 IgE 致敏与临床症状之间的关系。在鼻炎组（n=101）和对照组（n=101）中测量皮屑提取物和 sIgE 对宠物成分（Can f 1、Can f 2、Can f 3、Can f 5、Fel d 1、Fel 2 和 Fel 4）的致敏水平。

结果

鼻炎和非鼻炎患者中，狗（34.6%比 23.5%）和猫皮屑（26.7%比 8.8%，P=0.05）的 IgE 致敏率较高，与狗（29.7%比 20.5%）和猫（18.8%比 8.8%）的成分相似。鼻炎和非鼻炎患者中，狗（3.1，95%CI：1.5 至 6.1，P=0.05）的 IgE 致敏呈多态性，与狗（29.7%比 20.5%）和猫（18.8%比 8.8%）的成分相似。鼻炎和非鼻炎患者中，狗（3.1，95%CI：1.5 至 6.1，P=0.05）的 IgE 致敏呈多态性，与狗（29.7%比 20.5%）和猫（18.8%比 8.8%）的成分相似。鼻炎和非鼻炎患者中，狗（3.1，95%CI：1.5 至 6.1，P=0.05）的 IgE 致敏呈多态性，与狗（29.7%比 20.5%）和猫（18.8%比 8.8%）的成分相似。鼻炎和非鼻炎患者中，狗（3.1，95%CI：1.5 至 6.1，P=0.05）的 IgE 致敏呈多态性，与狗（29.7%比 20.5%）和猫（18.8%比 8.8%）的成分相似。鼻炎和非鼻炎患者中，狗（3.1，95%CI：1.5 至 6.1，P=0.05）的 IgE 致敏呈多态性，与狗（29.7%比 20.5%）和猫（18.8%比 8.8%）的成分相似。