Kellett H A, Collier A, Taylor R, Sawers J S, Benton C, Doig A, Baird D, Clarke B F
Diabetic Department, Royal Infirmary, Edinburgh, England.
Metabolism. 1988 Jul;37(7):656-9. doi: 10.1016/0026-0495(88)90085-6.
We report a young woman with systemic lupus erythematosis (SLE) who developed diabetes secondary to extreme insulin resistance, associated with severe hyperandrogenism and acanthosis nigricans. Her insulin resistance was found to be associated with high titers of insulin receptor antibodies. The hyperandrogenism has been favourably influenced by cyclical treatment with cyproterone acetate and ethinyl oestradiol, but the insulin resistance and acanthosis nigricans have remained unmodified after 15 months of follow up.
我们报告了一名患有系统性红斑狼疮（SLE）的年轻女性，她因极端胰岛素抵抗继发糖尿病，伴有严重高雄激素血症和黑棘皮病。发现她的胰岛素抵抗与高滴度的胰岛素受体抗体有关。醋酸环丙孕酮和炔雌醇的周期性治疗对高雄激素血症产生了有利影响，但在随访15个月后，胰岛素抵抗和黑棘皮病仍未改善。
