含糖饮料摄入与全因和特定原因死亡率的关联：日本基于公共卫生中心的前瞻性研究。
Association of sugary drink consumption with all-cause and cause-specific mortality: the Japan Public Health Center-based Prospective Study.
机构信息
Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
出版信息
Prev Med. 2021 Jul;148:106561. doi: 10.1016/j.ypmed.2021.106561. Epub 2021 Apr 15.
BACKGROUND
Few epidemiologic studies have assessed the associations of sugary drink consumption with mortality outcomes among Asian populations.
METHODS
This study included 70,486 participants in the Japan Public Health Center-based Prospective Study at the age of 45-74 years in 1995-1999. A validated food frequency questionnaire was used to assess the consumption of sugary drinks. We estimated the risk of total and cause-specific mortality associated with sugary drink consumption using Cox proportional hazards regression model.
RESULTS
Mean follow-up was 17.1 years, during which 11,811 deaths were documented. Sugary drink consumption was associated with higher total mortality, with multivariate HR of 1.06 (95% CI 1.00-1.13) for quintile 3, 1.07 (95% CI 1.01-1.13) for quintile 4, and 1.15 (95% CI 1.09-1.22) for quintile 5, compared with quintile 1 (P < 0.001 for trend). Additionally, positive associations with cause-specific mortality were observed, including death from circulatory system diseases (quintile 5 vs quintile 1; HR, 1.23; 95% CI 1.09-1.38) and heart disease (quintile 5 vs quintile 1; HR, 1.35; 95% CI 1.14-1.60).
CONCLUSION
In this large Japanese prospective study, sugary drink consumption was associated with all-cause and cause-specific mortality.
背景
很少有流行病学研究评估亚洲人群中含糖饮料摄入与死亡率结局之间的关系。
方法
本研究纳入了 1995 年至 1999 年日本公共卫生中心前瞻性研究中的 70486 名年龄在 45-74 岁的参与者。采用经过验证的食物频率问卷评估含糖饮料的摄入情况。我们使用 Cox 比例风险回归模型估计与含糖饮料摄入相关的总死亡率和死因特异性死亡率的风险。
结果
平均随访时间为 17.1 年，期间记录了 11811 例死亡。含糖饮料的摄入与总死亡率升高相关，与五分位 1 相比，五分位 3、五分位 4 和五分位 5 的多变量 HR 分别为 1.06（95%CI 1.00-1.13）、1.07（95%CI 1.01-1.13）和 1.15（95%CI 1.09-1.22）（P<0.001 趋势）。此外，还观察到与死因特异性死亡率的正相关，包括死于循环系统疾病（五分位 5 与五分位 1；HR，1.23；95%CI 1.09-1.38）和心脏病（五分位 5 与五分位 1；HR，1.35；95%CI 1.14-1.60）。
结论
在这项大型日本前瞻性研究中，含糖饮料的摄入与全因死亡率和死因特异性死亡率相关。
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