Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Epidemiology and Prevention Group, Division of Prevention, Center for Public Health Sciences, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Sci Rep. 2021 Nov 4;11(1):21701. doi: 10.1038/s41598-021-01103-x.
Globally, sugary drinks are widely consumed, however, few epidemiologic studies have investigated the association between sugary drink consumption and risk of kidney and bladder cancer. We examined the association of sugary drinks with risk of kidney and bladder cancer in 73,024 participants from the Japan Public Health Center-based Prospective Study who reported no history of cancer. Sugary drink consumption was assessed using a validated food frequency questionnaire at study baseline (1995-1999). Individuals were followed to December 31, 2013. Multivariable Cox proportional hazards regression models were used to calculate hazard ratios (HR) and 95% confidence intervals (CIs). During 1,069,815 person years of follow-up, 169 kidney cancer and 297 bladder cancer cases were documented. After adjusting for potential confounders, no greater risk of kidney and bladder cancer was observed. However, sugary drink consumption was positively associated with the risk of kidney cancer (HR for 100 ml/day increase in consumption was 1.11 [95% CI 1.01-1.22]) and bladder cancer (HR for 100 ml/d increase in consumption was 1.11 [95% CI 1.01-1.22]) among women after exclusion of cases diagnosed in the first three years of follow-up. In this large prospective cohort, consumption of sugary drinks was significantly associated with a small increase in hazard ratio for kidney and bladder cancer among women after exclusion of cases diagnosed within the first three years.
全球范围内，含糖饮料的消耗量巨大，然而，很少有流行病学研究调查含糖饮料的摄入与肾脏和膀胱癌风险之间的关联。我们在日本公共卫生中心前瞻性研究中，对 73024 名无癌症病史的参与者进行了研究，调查了含糖饮料的摄入与肾脏和膀胱癌风险之间的关系。在研究基线（1995-1999 年）时，使用经过验证的食物频率问卷评估了含糖饮料的摄入情况。随访至 2013 年 12 月 31 日。使用多变量 Cox 比例风险回归模型计算了危险比（HR）和 95%置信区间（CI）。在 1069815 人年的随访期间，记录了 169 例肾癌和 297 例膀胱癌病例。在调整了潜在混杂因素后，未观察到更高的肾癌和膀胱癌风险。然而，含糖饮料的摄入与肾癌风险呈正相关（每天增加 100ml 摄入的 HR 为 1.11 [95%CI 1.01-1.22]）和膀胱癌风险（每天增加 100ml/d 摄入的 HR 为 1.11 [95%CI 1.01-1.22]），但排除了随访前三年诊断的病例后，女性中观察到的风险更高。在这项大型前瞻性队列研究中，在排除随访前三年诊断的病例后，女性中含糖饮料的摄入量与肾脏和膀胱癌风险的 HR 略有增加显著相关。
