Department of Nuclear Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, 158, Paryong-ro, Masanhoewon-gu, Changwon, 51353, South Korea.
Hell J Nucl Med. 2021 Jan-Apr;24(1):10-17. doi: 10.1967/s002449912301. Epub 2021 Apr 20.
We investigated whether heat shock protein 90α (HSP90α) expression is associated with fluorine-18-labeled fluoro-2-deoxy-D-glucose (F-FDG) uptake and whether F-FDG positron emission tomography/computed tomography (PET/CT) can be used to predict the status of HSP90α expression in colorectal cancer (CRC).
The medical records and preoperative F-FDG PET/CT studies of 51 patients with newly diagnosed CRC who underwent surgical treatment were retrospectively reviewed. The maximum standardized uptake value (SUVmax) of the primary tumor was calculated from the level of F-FDG uptake. HSP90α expression was determined by immunohistochemistry. The relationship between SUVmax and HSP90α expression was analyzed.
Colorectal cancer with high HSP90α expression had significantly higher SUVmax than CRC with low HSP90α expression (18.88±10.06 vs. 12.38±5.04, P=0.003). There was a significant correlation between HSP90α expression and F-FDG uptake (r=0.354, P=0.011). The highest accuracy for determining HSP90α status (68.6%) was obtained with a SUVmax cut-off of 15.4. Maximum SUV was the only predictor of HSP90α expression on multivariate logistic regression analysis (Odds Ratio=5.384, P=0.016).
The expression status of HSP90α was significantly related to F-FDG uptake in CRC.
我们研究了热休克蛋白 90α（HSP90α）的表达是否与氟-18 标记的氟代-2-脱氧-D-葡萄糖（F-FDG）摄取有关，以及 F-FDG 正电子发射断层扫描/计算机断层扫描（PET/CT）是否可用于预测结直肠癌（CRC）中 HSP90α表达的状态。
回顾性分析了 51 例接受手术治疗的新诊断 CRC 患者的病历和术前 F-FDG PET/CT 研究。从 F-FDG 摄取水平计算原发肿瘤的最大标准化摄取值（SUVmax）。通过免疫组织化学测定 HSP90α的表达。分析 SUVmax与 HSP90α表达之间的关系。
HSP90α高表达的结直肠癌 SUVmax 显著高于 HSP90α低表达的 CRC（18.88±10.06 比 12.38±5.04，P=0.003）。HSP90α表达与 F-FDG 摄取之间存在显著相关性（r=0.354，P=0.011）。SUVmax 截断值为 15.4 时，确定 HSP90α状态的准确率最高（68.6%）。在多变量逻辑回归分析中，SUVmax 是 HSP90α表达的唯一预测因素（优势比=5.384，P=0.016）。
CRC 中 HSP90α 的表达状态与 F-FDG 摄取明显相关。
