Caprara I, Janssen P
Laboratorium voor Neuro-en Psychofysiologie, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Division of Biology and Biological Engineering, Computation and Neural Systems, Caltech, Pasadena, CA 91125, USA.
Cereb Cortex. 2021 Jul 29;31(9):4274-4288. doi: 10.1093/cercor/bhab085.
Efficient object grasping requires the continuous control of arm and hand movements based on visual information. Previous studies have identified a network of parietal and frontal areas that is crucial for the visual control of prehension movements. Electrical microstimulation of 3D shape-selective clusters in AIP during functional magnetic resonance imaging activates areas F5a and 45B, suggesting that these frontal areas may represent important downstream areas for object processing during grasping, but the role of area F5a and 45B in grasping is unknown. To assess their causal role in the frontal grasping network, we reversibly inactivated 45B, F5a, and F5p during visually guided grasping in macaque monkeys. First, we recorded single neuron activity in 45B, F5a, and F5p to identify sites with object responses during grasping. Then, we injected muscimol or saline to measure the grasping deficit induced by the temporary disruption of each of these three nodes in the grasping network. The inactivation of all three areas resulted in a significant increase in the grasping time in both animals, with the strongest effect observed in area F5p. These results not only confirm a clear involvement of F5p, but also indicate causal contributions of area F5a and 45B in visually guided object grasping.
高效的物体抓握需要基于视觉信息对手臂和手部运动进行持续控制。先前的研究已经确定了一个顶叶和额叶区域网络，该网络对于抓握动作的视觉控制至关重要。在功能磁共振成像期间，对AIP中3D形状选择性簇进行电微刺激会激活F5a和45B区域，这表明这些额叶区域可能是抓握过程中物体处理的重要下游区域，但F5a和45B区域在抓握中的作用尚不清楚。为了评估它们在额叶抓握网络中的因果作用，我们在猕猴视觉引导抓握过程中可逆性地失活了45B、F5a和F5p区域。首先，我们记录了45B、F5a和F5p区域的单个神经元活动，以识别抓握过程中对物体有反应的位点。然后，我们注射蝇蕈醇或生理盐水，以测量抓握网络中这三个节点中的每一个暂时中断所引起的抓握缺陷。所有三个区域的失活都导致两只动物的抓握时间显著增加，其中在F5p区域观察到的影响最强。这些结果不仅证实了F5p区域明显参与其中，还表明F5a和45B区域在视觉引导的物体抓握中具有因果作用。
