Fischer S H, Ochs H D, Wedgwood R J, Skvaril F, Morell A, Hill H R, Schiffmann G, Corey L
Department of Pediatrics, University of Washington School of Medicine, Seattle.
Monogr Allergy. 1988;23:225-35.
To measure the survival of IgG, IgG subclasses and antigen-specific antibody in immune-deficient patients, we infused 4 patients with X-linked agammaglobulinemia (XLA) and 6 patients with common variable immune deficiency (CVID) with modified immunoglobulin at a dose of 400 mg/kg per month until steady state was reached. Following the 8th monthly infusion, serial samples were obtained and analyzed for serum concentration of IgG, IgG subclasses and for specific antibody activities against a battery of antigens. Half-lives for IgG and IgG subclasses were between 30 and 40 days except for IgG3 which appeared to consist of two populations of molecules, one showing a rapid decay, the other disappearing at a rate suggesting a half life of 22-24 days. Antigen-specific antibodies, including antibodies to HBsAg, cytomegalovirus, pneumococcal polysaccharides and streptococcal group A carbohydrate were similar to that for total IgG. These studies demonstrate that protective antibody titers to infective agents can be maintained for several weeks following high-dose intravenous immunoglobulin infusion.
为了测定免疫缺陷患者体内IgG、IgG亚类和抗原特异性抗体的存活情况，我们对4例X连锁无丙种球蛋白血症（XLA）患者和6例常见变异型免疫缺陷（CVID）患者每月输注剂量为400mg/kg的改良免疫球蛋白，直至达到稳态。在第8次每月输注后，采集系列样本并分析IgG、IgG亚类的血清浓度以及针对一系列抗原的特异性抗体活性。IgG和IgG亚类的半衰期在30至40天之间，但IgG3似乎由两类分子组成，一类显示快速衰减，另一类以提示半衰期为22 - 24天的速率消失。抗原特异性抗体，包括针对乙肝表面抗原、巨细胞病毒、肺炎球菌多糖和A组链球菌碳水化合物的抗体，与总IgG的情况相似。这些研究表明，在大剂量静脉注射免疫球蛋白输注后，针对感染因子的保护性抗体滴度可维持数周。
