长期静脉替代治疗后γ球蛋白半衰期延长。
Increased half-life of gammaglobulin after prolonged intravenous replacement therapy.
作者信息
Lever A M, Yap P L, Cuthbertson B, Wootton R, Webster A D
出版信息
Clin Exp Immunol. 1987 Feb;67(2):441-6.
Abstract
The half-life of total IgG and antibodies to cytomegalovirus and pneumococcal polysaccharide type III was consistently prolonged after a 9 month course of intravenous gammaglobulin treatment in three patients with 'primary' hypogammaglobulinaemia. The half-life of antibody to tetanus toxoid showed no consistent pattern. These data are at variance with the traditional dogma that IgG half-life is inversely related to serum IgG concentration. They suggest that patients on intravenous gammaglobulin therapy are likely to need less, rather than more, infusions when their serum IgG has risen to within the physiological range.
摘要
在三名“原发性”低丙种球蛋白血症患者接受9个月的静脉注射丙种球蛋白治疗后，总IgG以及针对巨细胞病毒和Ⅲ型肺炎球菌多糖的抗体的半衰期持续延长。破伤风类毒素抗体的半衰期则没有一致的规律。这些数据与传统观点即IgG半衰期与血清IgG浓度呈负相关相矛盾。它们表明，接受静脉注射丙种球蛋白治疗的患者在血清IgG升至生理范围内时，可能需要更少而非更多的输注。
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