Calancie B M, Stein R B
Department of Physiology, University of Alberta, Edmonton, Canada.
Muscle Nerve. 1988 Jun;11(6):638-44. doi: 10.1002/mus.880110617.
The purpose of this study was to examine whether a microneurography electrode could record from and then selectively stimulate the same afferent fiber in cat sural and tibial nerves. Fiber activity was recorded distally with microneurography needle electrodes and proximally with hook electrodes. Records from the hook electrodes allowed the waveform shape and latency following natural stimulation to be compared with that produced by electrical stimuli delivered through the needle electrode. The action potentials from approximately 50% of the recorded fibers failed to propagate beyond the needle electrode. When propagation did occur and the comparison could be made, only 25% of the afferents recorded could be selectively stimulated. This relatively low success rate suggests that a typical microneurography needle is not particularly good for selectively stimulating identified afferents. Thus in human experiments, attempts to microstimulate identified afferents may often include stimulation of unidentified alternative, or additional, afferent fibers at thresholds of sensory perception.
本研究的目的是检验微神经图电极能否记录猫腓肠神经和胫神经中同一传入纤维的活动，然后对其进行选择性刺激。纤维活动通过微神经图针电极在远端记录，通过钩状电极在近端记录。钩状电极的记录结果使得自然刺激后的波形形状和潜伏期能够与通过针电极施加电刺激所产生的波形形状和潜伏期进行比较。大约50%的记录纤维的动作电位未能传播到针电极之外。当传播确实发生且能够进行比较时，所记录的传入纤维中只有25%能够被选择性刺激。这种相对较低的成功率表明，典型的微神经图针在选择性刺激已识别的传入纤维方面并不是特别有效。因此，在人体实验中，对已识别的传入纤维进行微刺激的尝试可能常常包括在感觉阈值水平刺激未识别的替代或额外传入纤维。
