Department of Perinatology, Etlik Zubeyde Hanim Women's Health Care, Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
J Matern Fetal Neonatal Med. 2022 Mar;35(5):832-836. doi: 10.1080/14767058.2021.1910666. Epub 2021 Apr 18.
To understand if every other day iron supplementation may be as effective as daily iron intake in anemic pregnant women.
This case-control study was conducted at a tertiary hospital in Turkey. The study randomly categorized women into two groups as daily intake ( = 124) vs every other day intake ( = 140) of 100 mg daily oral ferrous fumarate. The numbers of women recruited from the study were 13 and 34 in two groups. Thus, for analysis, there were 111 women in the daily group and 106 women in the other group. The current study obtained hemoglobin (Hb) and ferritin levels two times to evaluate the effects of treatment, noting initial levels before drug administration, and a second blood sample was obtained after two months. Two groups were compared according to the increase in Hb and ferritin levels. The study asked the women whether they experienced gastrointestinal side effects.
The ferritin levels increased 4.9 ± 4.2 ng/mL in the daily intake group and 3.9 ± 2.9 ng/mL in every other day group ( = .215). The Hb increased 1.4 ± 0.7 g/dL in the daily intake group and 1.6 ± 0.6 g/dL in the other group ( = .021). Gastrointestinal side effects appeared in 47 (17.8%) out of 264 women. The rate of gastrointestinal side effect was lower in every other day group (41.4% vs 15.1%, = .0057).
Every other day iron supplementation is as effective as daily intake for treating iron deficiency anemia with lesser gastrointestinal side effects during pregnancy.
了解在贫血孕妇中，隔一天补充铁剂是否与每日补铁一样有效。
这是一项在土耳其一家三级医院进行的病例对照研究。该研究将女性随机分为每日摄入组（ = 124）和隔一天摄入组（ = 140），每天口服 100 毫克富马酸亚铁。两组分别招募了 13 名和 34 名女性。因此，在分析中，每日组有 111 名女性，另一组有 106 名女性。本研究两次测量血红蛋白（Hb）和铁蛋白水平以评估治疗效果，记录药物治疗前的初始水平，并在两个月后采集第二份血样。根据 Hb 和铁蛋白水平的升高来比较两组。研究询问女性是否有胃肠道副作用。
每日摄入组铁蛋白水平升高 4.9 ± 4.2 ng/mL，隔一天摄入组升高 3.9 ± 2.9 ng/mL（ = .215）。每日摄入组 Hb 升高 1.4 ± 0.7 g/dL，隔一天摄入组升高 1.6 ± 0.6 g/dL（ = .021）。264 名女性中有 47 名（17.8%）出现胃肠道副作用。隔一天摄入组胃肠道副作用发生率较低（41.4% vs 15.1%， = .0057）。
隔一天补充铁剂与每日补铁一样有效，可治疗妊娠期缺铁性贫血，且胃肠道副作用较少。
